[HTML][HTML] Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease
R Nielsen, EI Christensen, H Birn - Kidney international, 2016 - Elsevier
Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …
Megaloblastic anemias: nutritional and other causes
Ineffective DNA synthesis in hematopoietic precursor cells is the primary mechanism that
leads to megaloblastic anemia. The most frequent causes of megaloblastic anemia are …
leads to megaloblastic anemia. The most frequent causes of megaloblastic anemia are …
Endocytic receptors in the renal proximal tubule
Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …
Gut microbiota-derived vitamins–underrated powers of a multipotent ally in psychiatric health and disease
Despite the well-established roles of B-vitamins and their deficiencies in health and disease,
there is growing evidence indicating a key role of those nutrients in functions of the central …
there is growing evidence indicating a key role of those nutrients in functions of the central …
Vitamin B12 absorption: mammalian physiology and acquired and inherited disorders
R Kozyraki, O Cases - Biochimie, 2013 - Elsevier
BACKGROUND: Vitamin B12 (cobalamin) is a cobalt-containing compound synthesized by
bacteria and an essential nutrient in mammals, which take it up from diet. The absorption …
bacteria and an essential nutrient in mammals, which take it up from diet. The absorption …
[HTML][HTML] Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns
SM Tanner, AC Sturm, EC Baack… - Orphanet journal of rare …, 2012 - Springer
Background Inherited malabsorption of cobalamin (Cbl) causes hematological and
neurological abnormalities that can be fatal. Three genes have been implicated in Cbl …
neurological abnormalities that can be fatal. Three genes have been implicated in Cbl …
[HTML][HTML] Detailed investigations of proximal tubular function in Imerslund-Gräsbeck syndrome
Abstract Background Imerslund-Gräsbeck Syndrome (IGS) is a rare genetic disorder
characterised by juvenile megaloblastic anaemia. IGS is caused by mutations in either of the …
characterised by juvenile megaloblastic anaemia. IGS is caused by mutations in either of the …
Cubilin, the intrinsic factor-vitamin B12 receptor in development and disease
R Kozyraki, O Cases - Current medicinal chemistry, 2020 - ingentaconnect.com
Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor
serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic …
serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic …
[HTML][HTML] Novel compound heterozygous mutations in AMN cause Imerslund-Gräsbeck syndrome in two half-sisters: a case report
E Montgomery, JA Sayer, LA Baines, AM Hynes… - BMC medical …, 2015 - Springer
Abstract Background Imerslund-Gräsbeck Syndrome (IGS) is a rare autosomal recessive
disease characterized by intestinal vitamin B12 malabsorption. Clinical features include …
disease characterized by intestinal vitamin B12 malabsorption. Clinical features include …