Docking is a computational technique that places a small molecule (ligand) in the binding
site of its macromolecular target (receptor) and estimates its binding affinity. This review …

Artificial Intelligence revolutionizes the drug development process that can quickly identify
potential biologically active compounds from millions of candidate within a short period. The …

Since the outbreak of the COVID-19 pandemic in December 2019 and its rapid spread
worldwide, the scientific community has been under pressure to react and make progress in …

The inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main
protease (Mpro) and papain-like protease (PLpro) prevents viral multiplications; these viral …

The scientific community is working against the clock to arrive at therapeutic interventions to
treat patients with COVID-19. Among the strategies for drug discovery, virtual screening …

In the present study, the silver nanoparticles (AgNPs) were synthesized from the bulbs of
Allium sativum, characterized by UV–visible spectroscopy, FT-IR, SEM, HR-TEM, EDAX …

Intracellular Ca2+ dysregulation is a key marker in septic cardiac dysfunction; however,
regulation of the classic Ca2+ regulatory modules cannot successfully abolish this symptom …

Coronaviruses (CoV) are enveloped positive-stranded RNA viruses and, historically, there
are seven known human-infecting CoVs with varying degrees of virulence. CoV attachment …

The antitumor activity of the newly synthesized 5-arylidenethiazolidine-2, 4-dione derivatives
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …

Purpose Despite a growing body of evidence indicating a potential efficacy of the anti-
diabetic metformin as anti-cancer agent, the exact mechanism underlying this efficacy has …