MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

The Sp/KLF family contains at least twenty identi® ed members which include Sp1-4 and
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …

Structural remodeling of the ventricular wall is a key determinant of clinical outcome in heart
disease. Such remodeling involves the production and destruction of extracellular matrix …

Krüppel-like factors (KLFs) 1 are DNA-binding transcriptional regulators that play diverse
roles during differentiation and development. They form a subset of the broad class of …

Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to play a pivotal role in
the pathogenesis of cardiovascular disease. Here, we show that neonatal heterozygous …

Recent advances in molecular cloning have led to the identification of a large number of
mammalian zinc finger-containing transcription factors that exhibit homology to the …

We recently isolated a Krüppel-like zinc-finger transcription factor 5 (KLF5; also known as
BTEB2 and IKLF), which is markedly induced in activated vascular smooth-muscle cells and …

Stromal cells generated in long-term cultures appear to follow a vascular smooth muscle
differentiation pathway. Such a pathway, comprising several steps hallmarked by the …