MrGPS: An m6A-related gene pair signature to predict the prognosis and immunological impact of glioma patients

N Zhang, F Yang, P Zhao, N Jin, H Wu… - Briefings in …, 2024 - academic.oup.com
Abstract N6-methyladenosine (m6A) RNA methylation is the predominant epigenetic
modification for mRNAs that regulates various cancer-related pathways. However, the …

Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy

S Chen, M Huang, D Xu, M Li - Neurochemistry International, 2023 - Elsevier
Epilepsy is a common neurological disorder characterized by recurrent seizures with
excessive and abnormal neuronal discharges. Epileptogenesis is usually involved in …

Unraveling the RNA Tapestry: A Symphony of Innovations in m6A Research Technology

S Fei, ZW Fang, BS Zhao - Israel Journal of Chemistry, 2024 - Wiley Online Library
This review navigates the evolving landscape of N6‐methyladenosine (m6A) research
approaches, emphasizing the importance of advanced technology in understanding RNA …

Single-cell discovery of m6A RNA modifications in the hippocampus

S Feng, M Tellaetxe-Abete, Y Zhang, Y Peng… - Genome …, 2024 - genome.cshlp.org
N 6-Methyladenosine (m6A) is a prevalent and highly regulated RNA modification essential
for RNA metabolism and normal brain function. It is particularly important in the …

TRPML1 ameliorates seizures-related neuronal injury by regulating autophagy and lysosomal biogenesis via Ca2+/TFEB signaling pathway

T Peng, Y Xie, S Zhao, X Wang, W Zhang, Y Xie… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Alterations in autophagy have been observed in epilepsy, although their exact
etiopathogenesis remains elusive. Transient Receptor Potential Mucolipin Protein 1 …

Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin

J Zhou, S Liao, C Zhang, J Luo, G Li, H Li - Molecular Biology Reports, 2023 - Springer
Background Abnormal methylation of N 6-methyladenosine (m6A) is reportedly associated
with central nervous system disorders. However, the role of m6A mRNA methylation in …

m6A/m1A/m5C-Associated Methylation Alterations and Immune Profile in MDD

X Ren, Z Feng, X Ma, L Huo, H Zhou, A Bai… - Molecular …, 2024 - Springer
Major depressive disorder (MDD) is a prevalent psychiatric condition often accompanied by
severe impairments in cognitive and functional capacities. This research was conducted to …

METTL14/YTHDC1-mediated m6A modification in hippocampus improves pentylenetetrazol-induced acute seizures

X Zhong, L Chen, Y Wang, Y Liang, Y Huang… - Molecular …, 2024 - Springer
Epilepsy is a common neurological disorder which can cause significant morbidity and
mortality. N6-methyladenosine (m6A), the most common chemical epigenetic modification …

Unveiling the role of RNA methylation in glioma: Mechanisms, prognostic biomarkers, and therapeutic targets

Q Xu, C Yang, L Wang, J Zhou - Cellular Signalling, 2024 - Elsevier
Gliomas, the most prevalent malignant brain tumors in the central nervous system, are
marked by rapid growth, high recurrence rates, and poor prognosis. Glioblastoma (GBM) …

The complex roles of m6A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative …

Y Li, J Xue, Y Ma, K Ye, X Zhao, F Ge… - Neural Regeneration …, 2025 - journals.lww.com
Abstract N6-methyladenosine (m 6 A), the most prevalent and conserved RNA modification
in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA …