Karyotype complexity has major prognostic value in many malignancies. There is no
consensus on the definition of a complex karyotype, and the prognostic impact of karyotype …

Personalized treatment is an attractive strategy that promises increased efficacy with
reduced side effects in cancer. The feasibility of such an approach has been greatly boosted …

Cytogenetics has long represented a critical component in the clinical evaluation of
hematologic malignancies. Chromosome banding studies provide a simultaneous snapshot …

Complex karyotype identified by chromosome-banding analysis has been shown to have
prognostic value in chronic lymphocytic leukemia (CLL). Genomic arrays offer high …

The detection of acquired copy-number abnormalities (CNAs) and copy-neutral loss of
heterozygosity (CN-LOH) in neoplastic disorders by chromosomal microarray analysis …

Optical genome mapping (OGM) is a new genome-wide technology that can reveal both
structural genomic variations (SVs) and copy number variations (CNVs) in a single assay …

Fluorescence in situ hybridization (FISH) is currently the gold-standard assay to detect
recurrent genomic abnormalities of prognostic significance in multiple myeloma (MM). Since …

Background Risk stratification in multiple myeloma (MM) patients is crucial, and molecular
genetic studies play a significant role in achieving this objective. Enrichment of plasma cells …

Cytogenomic analyses of acquired clonal chromosomal abnormalities in neoplastic blood,
bone marrow, and/or lymph nodes are instrumental in the clinical management of patients …

Objectives Fluorescence in situ hybridization (FISH) for plasma cell neoplasms (PCNs)
requires plasma cell (PC) identification or purification strategies to optimize results. We …