Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …

Abstract Arginase 1 (ARG1) inactivates T cells by degrading L-arginine, severely reducing
the immunotherapeutic efficacy. Effectively blocking the ARG1 pathway remains a …

The past several years have seen tremendous advances in the engineering of immune
effector cells as therapy for cancer. While chimeric antigen receptors (CARs) have been …

Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically
been notable worldwide and many attempts have been made to raise the overall survival of …

Natural killer (NK) cells are innate lymphoid cells that are important effectors in the first line
of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms …

Although cancer immunotherapy based on immune checkpoint inhibitors holds great
promise toward many types of cancers, several challenges still remain, associated with low …

Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because
glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that …

Natural killer (NK) cells are essential components of the innate immune system and play a
critical role in host immunity against cancer. Recent progress in our understanding of NK cell …

Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors
have successfully improved outcomes in several tumor types. In addition, currently, immune …