[HTML][HTML] Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes

Y Wang, S Wu, Q Li, H Sun, H Wang - Advanced Science, 2023 - Wiley Online Library
Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

A novel anti-osteoporosis mechanism of VK2: interfering with ferroptosis via AMPK/SIRT1 pathway in type 2 diabetic osteoporosis

C Jin, K Tan, Z Yao, B Lin, D Zhang… - Journal of Agricultural …, 2023 - ACS Publications
Type 2 diabetic osteoporosis (T2DOP) is a chronic bone metabolic disease. Compared with
traditional menopausal osteoporosis, the long-term high glucose (HG) microenvironment …

[HTML][HTML] Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases

Y Wang, M Lv, W Zhao - Ageing research reviews, 2023 - Elsevier
Ferroptosis is an iron-and lipid peroxidation (LPO)-mediated programmed cell death type.
Recently, mounting evidence has indicated the involvement of ferroptosis in …

[HTML][HTML] Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: a review

D Zhao, K Yang, H Guo, J Zeng, S Wang, H Xu… - Biomedicine & …, 2023 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

[HTML][HTML] Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice

S Yang, L Wang, Y Zeng, Y Wang, T Pei, Z Xie, Q Xiong… - Phytomedicine, 2023 - Elsevier
Background Alzheimer's disease (AD) is a neurogenerative disease and remains no
effective method for stopping its progress. Ferroptosis and adaptive immunity have been …

[HTML][HTML] Pharmacological effects of salidroside on central nervous system diseases

M Jin, C Wang, Y Xu, Z Zhang, X Wu, R Ye… - Biomedicine & …, 2022 - Elsevier
Salidroside (SAL) is a phenylpropanoid glycoside monomer extracted from Rhodiola at high
altitudes. It has been proven to have protective effects on myocardial injury, liver cancer …

[HTML][HTML] Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the …

J Xu, L Zhao, X Zhang, K Ying, R Zhou, W Cai… - Ecotoxicology and …, 2023 - Elsevier
Acetaminophen (APAP) overdose has long been considered a major cause of drug-induced
liver injury. Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid …

Ferroptosis-regulated cell death as a therapeutic strategy for neurodegenerative diseases: current status and future prospects

JB Zhang, X Jia, Q Cao, YT Chen, J Tong… - ACS chemical …, 2023 - ACS Publications
Ferroptosis is increasingly being recognized as a key element in the pathogenesis of
diverse diseases. Recent studies have highlighted the intricate links between iron …

Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis

Y Wang, Z Chen, J Luo, J Zhang, A Sang… - International …, 2023 - Elsevier
Background Ferroptosis, an iron-dependent programmed necrosis, is linked to lung
ischemia–reperfusion injury. Salidroside is a glycoside derived from the Rhodiola rosea …