Homocysteine–from disease biomarker to disease prevention
AD Smith, H Refsum - Journal of internal medicine, 2021 - Wiley Online Library
We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …
that are associated with raised concentrations of plasma total homocysteine. The …
[HTML][HTML] Biomarkers and algorithms for the diagnosis of vitamin B12 deficiency
L Hannibal, V Lysne, AL Bjørke-Monsen… - Frontiers in molecular …, 2016 - frontiersin.org
Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that
serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial …
serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial …
Vitamin B12 deficiency
Abstract Vitamin B 12 (B12; also known as cobalamin) is a B vitamin that has an important
role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial …
role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial …
Vitamin B12
The biosynthesis of B 12, involving up to 30 different enzyme-mediated steps, only occurs in
bacteria. Thus, most eukaryotes require an external source of B 12, and yet the vitamin …
bacteria. Thus, most eukaryotes require an external source of B 12, and yet the vitamin …
Cobalamin coenzyme forms are not likely to be superior to cyano‐and hydroxyl‐cobalamin in prevention or treatment of cobalamin deficiency
R Obeid, SN Fedosov, E Nexo - Molecular nutrition & food …, 2015 - Wiley Online Library
Methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl) are coenzymes for methionine
synthase and methylmalonyl‐CoA mutase, respectively. Hydroxylcobalamin (HOCbl) and …
synthase and methylmalonyl‐CoA mutase, respectively. Hydroxylcobalamin (HOCbl) and …
Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B12 metabolism
JL Guéant, RM Guéant-Rodriguez… - Critical reviews in …, 2022 - Taylor & Francis
Abstract Methyl-Cobalamin (Cbl) derives from dietary vitamin B12 and acts as a cofactor of
methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of …
methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of …
[HTML][HTML] Comparative bioavailability and utilization of particular forms of B12 supplements with potential to mitigate B12-related genetic polymorphisms
C Paul, DM Brady - Integrative Medicine: A Clinician's Journal, 2017 - ncbi.nlm.nih.gov
Objective This study had 3 objectives:(1) To summarize and compare assimilation pathways
for 4 B 12 forms;(2) to determine whether supplementation with a particular B 12 form (or …
for 4 B 12 forms;(2) to determine whether supplementation with a particular B 12 form (or …
Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy
T Chern, A Achilleos, X Tong, MC Hill… - Nature …, 2022 - nature.com
Combined methylmalonic acidemia and homocystinuria (cblC) is the most common inborn
error of intracellular cobalamin metabolism and due to mutations in Methylmalonic Aciduria …
error of intracellular cobalamin metabolism and due to mutations in Methylmalonic Aciduria …
SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induced by inherited cobalamin disorders
R Ghemrawi, C Arnold, SF Battaglia-Hsu, G Pourié… - Metabolism, 2019 - Elsevier
Background The molecular consequences of inborn errors of vitamin B12 or cobalamin
metabolism are far from being understood. Moreover, innovative therapeutic strategies are …
metabolism are far from being understood. Moreover, innovative therapeutic strategies are …
[HTML][HTML] Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC
An increasing number of studies indicate that each step of the intracellular processing of
vitamin B12 or cobalamin (Cbl) involves protein-protein interactions. We have previously …
vitamin B12 or cobalamin (Cbl) involves protein-protein interactions. We have previously …