Poor aqueous solubility and poor bioavailability are major issues with many pharmaceutical
industries. By some estimation, 70–90% drug candidates in development stage while up-to …

BCS class IV drugs (eg, amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel)
exhibit many characteristics that are problematic for effective oral and per oral delivery …

Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting
approach for poorly soluble drugs. Nanocrystals provide special features including …

As nano-sizing is becoming a more common approach for pharmaceutical product
development, researchers are taking advantage of the unique inherent properties of …

Rapid advancement in drug discovery process is leading to a number of potential new drug
candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the …

Poor aqueous solubility represents a major hurdle in achieving adequate oral bioavailability
for a large percentage of drug compounds in drug development nowadays. Nanosizing …

The drug candidates coming from combinatorial chemistry research and/or the drugs
selected from biologically based high-throughput screening are quite often very lipophilic, as …

More than 40% of compounds identified through combinatorial screening programs are
poorly soluble in water. These molecules are difficult to formulate using conventional …

In this paper work, four naked nanocrystals (size range 80–700 nm) were prepared without
any surfactant or polymer using the solvent/nonsolvent method. The effects of particle size …

Objectives Wet milling is a common technique to produce drug nanocrystals. Stability of the
nanocrystals is a critical question, and different kinds of stabilizers, eg polymers, celluloses …