Causes and consequences of aneuploidy in cancer
Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …
Cancer chromosomal instability: therapeutic and diagnostic challenges: 'Exploring aneuploidy: the significance of chromosomal imbalance'review series
N McGranahan, RA Burrell, D Endesfelder… - EMBO …, 2012 - embopress.org
Chromosomal instability (CIN)—which is a high rate of loss or gain of whole or parts of
chromosomes—is a characteristic of most human cancers and a cause of tumour aneuploidy …
chromosomes—is a characteristic of most human cancers and a cause of tumour aneuploidy …
[HTML][HTML] Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome
Aneuploidy has been recognized as a hallmark of cancer for more than 100 years, yet no
general theory to explain the recurring patterns of aneuploidy in cancer has emerged. Here …
general theory to explain the recurring patterns of aneuploidy in cancer has emerged. Here …
Single-chromosome gains commonly function as tumor suppressors
JM Sheltzer, JH Ko, JM Replogle, NCH Burgos… - Cancer cell, 2017 - cell.com
Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here,
we investigated the relationship between aneuploidy and cancer development using cells …
we investigated the relationship between aneuploidy and cancer development using cells …
Replication protein A: single‐stranded DNA's first responder: dynamic DNA‐interactions allow replication protein A to direct single‐strand DNA intermediates into …
Replication protein A (RPA), the major single‐stranded DNA‐binding protein in eukaryotic
cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in …
cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in …
Hypoxic culture conditions as a solution for mesenchymal stem cell based regenerative therapy
Cell‐based regenerative therapies, based on in vitro propagation of stem cells, offer
tremendous hope to many individuals suffering from degenerative diseases that were …
tremendous hope to many individuals suffering from degenerative diseases that were …
Chromosomal instability and aneuploidy in cancer: from yeast to man: 'Exploring aneuploidy: the significance of chromosomal imbalance'review series
Aneuploidy is frequently associated with disease and developmental abnormalities. It is also
a key characteristic of cancer. Several model systems have been developed to study the role …
a key characteristic of cancer. Several model systems have been developed to study the role …
New insights into the troubles of aneuploidy
JJ Siegel, A Amon - Annual review of cell and developmental …, 2012 - annualreviews.org
Deviation from a balanced genome by either gain or loss of entire chromosomes is generally
tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell …
tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell …
Whole-genome duplication shapes the aneuploidy landscape of human cancers
Aneuploidy is a hallmark of cancer with tissue-specific prevalence patterns that suggest it
plays a driving role in cancer initiation and progression. However, the contribution of …
plays a driving role in cancer initiation and progression. However, the contribution of …
Whole-genome sequencing reveals diverse models of structural variations in esophageal squamous cell carcinoma
Comprehensive identification of somatic structural variations (SVs) and understanding their
mutational mechanisms in cancer might contribute to understanding biological differences …
mutational mechanisms in cancer might contribute to understanding biological differences …