The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone,
inhibits platelet function, prevents adhesion of leukocytes, and reduces proliferation of the …

Nitric oxide (NO·) is an important protective molecule in the vasculature, and endothelial NO·
synthase (eNOS) is responsible for most of the vascular NO· produced. A functional eNOS …

Patients with cancer have an impaired T‐cell response that can decrease the potential
therapeutic benefit of cancer vaccines and other forms of immunotherapy. l‐arginine (l‐Arg) …

The vitamin D hormone 1α, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3] is essential for the
preservation of serum calcium and phosphate levels but may also be important for the …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Arginine has multiple metabolic fates and thus is one of the most versatile amino acids. Not
only is it metabolically interconvertible with the amino acids proline and glutamate, but it also …