[HTML][HTML] Flaxseed lignans as important dietary polyphenols for cancer prevention and treatment: Chemistry, pharmacokinetics, and molecular targets

SF De Silva, J Alcorn - Pharmaceuticals, 2019 - mdpi.com
Cancer causes considerable morbidity and mortality across the world. Socioeconomic,
environmental, and lifestyle factors contribute to the increasing cancer prevalence …

Natural polyphenols for drug delivery and tissue engineering construction: A review

Y Liu, Y Shi, M Zhang, F Han, W Liao, X Duan - European Journal of …, 2024 - Elsevier
Polyphenols, natural compounds rich in phenolic structures, are gaining prominence due to
their antioxidant, anti-inflammatory, antibacterial, and anticancer properties, making them …

[PDF][PDF] Treatment with flaxseed oil induces apoptosis in cultured malignant cells

AL Buckner, CA Buckner, S Montaut, RM Lafrenie - Heliyon, 2019 - cell.com
Flaxseed oil is widely recognized for its exceptional nutritional value, high concentration of
fiber-based lignans and large amounts of ω-fatty acids. It is one of a generic group of …

Effect of dietary flaxseed intake on circulating sex hormone levels among postmenopausal women: a randomized controlled intervention trial

VC Chang, M Cotterchio, BA Boucher… - Nutrition and …, 2019 - Taylor & Francis
Lignan intake, and its richest food source, flaxseed, have been associated with reduced
breast cancer risk. Endogenous sex hormones, such as estrogens, play a role in breast …

[HTML][HTML] Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in …

P Pal, K Hales, J Petrik, DB Hales - Journal of Ovarian Research, 2019 - Springer
Background We have previously shown that a whole flaxseed supplemented diet decreased
the onset and severity of ovarian cancer in the laying hen, the only known animal model of …

[HTML][HTML] Enterolactone has stronger effects than enterodiol on ovarian cancer

H Liu, J Liu, S Wang, Z Zeng, T Li, Y Liu… - Journal of ovarian …, 2017 - Springer
Background Ovarian cancer is one of the three leading gynecological malignancies,
characterized by insidious growth, highly frequent metastasis, and quick development of …

[HTML][HTML] Honokiol inhibits the growth of hormone-resistant breast cancer cells: its promising effect in combination with metformin

EI Mikhaevich, DV Sorokin… - Research in …, 2023 - journals.lww.com
Background and purpose: Primary and metastatic breast cancers still represent an unmet
clinical need for improved chemotherapy and hormone therapy. Considerable attention has …

Flaxseed and its components differentially affect estrogen targets in pre-neoplastic hen ovaries

A Dikshit, C Gao, C Small, K Hales, DB Hales - The Journal of steroid …, 2016 - Elsevier
Flaxseed has been studied for decades for its health benefits that include anti-cancer, cardio-
protective, anti-diabetic, anti-inflammatory properties. The biologically active components …

Performance and egg quality of laying hens fed flaxseed: Highlights on n-3 fatty acids, cholesterol, lignans and isoflavones

S Mattioli, S Ruggeri, B Sebastiani, G Brecchia… - Animal, 2017 - cambridge.org
Flaxseed is a rich source of α-linolenic acid and phytoestrogens, mainly lignans, whose
metabolites (enterodiol and enterolactone) can affect estrogen functions. The present study …

[HTML][HTML] Therapeutic effect of flax-based diets on fatty liver in aged laying hens

JE Davis, J Cain, C Small, DB Hales - Poultry Science, 2016 - Elsevier
This study examined the ability of flax-based ingredients to attenuate nonalcoholic fatty liver
disease (NAFLD) in aged laying hens—a novel and more physiologically relevant model of …