Brain diseases are one of the most socially and economically burdening diseases in
Europe. Among all brain diseases, more than 60% of social and economic costs are …

The gut‐brain axis is increasingly recognized as an important pathway of communication
and of physiological regulation, and gut microbiota seems to play a significant role in this …

Background Late-life depressive symptoms have been extensively studied for their
relationship with incident dementia, but have been typically assessed at a single timepoint …

Major depressive disorder (MDD) is a leading cause of disability worldwide. After the first
episode, patients with remitted MDD have a 60% chance of experiencing a second episode …

Radial glial-like cells (RGLs) in the adult dentate gyrus (DG) function as progenitor cells for
adult hippocampal neurogenesis, a process involved in the stress-related pathophysiology …

Major depressive disorder (MDD) is widely accepted as having a heterogenous
pathophysiology involving a complex mixture of systemic and CNS processes. A …

The pathophysiological underpinnings of neuroprogressive processes in recurrent major
depressive disorder (rMDD) are reviewed. A wide array of biochemical processes underlie …

Background Major depressive disorder (MDD) affects a quarter of adolescents and young
adults and is associated with the greatest global burden of disease in this population. There …

The comorbid prevalence of major depressive disorder (MDD) with obesity and type II
diabetes mellitus reflects the existence of a subset of individuals with a complex common …

The exact pathophysiology of major depressive disorder (MDD) remains elusive. The
monoamine theory, which hypothesizes that MDD emerges as a result of dysfunctional …