[HTML][HTML] Regulatory role of l-proline in fetal pig growth and intestinal epithelial cell proliferation

J Wang, J Li, X Kong, M Tan, G Wu - Animal nutrition, 2020 - Elsevier
Abstract l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via
ornithine decarboxylase (ODC). Polyamines plays a key role in the proliferation of intestinal …

[HTML][HTML] Polyamine depletion attenuates isoproterenol-induced hypertrophy and endoplasmic reticulum stress in cardiomyocytes

Y Lin, X Zhang, L Wang, Y Zhao, H Li, W Xiao… - Cellular Physiology and …, 2014 - karger.com
Background/Aim: Polyamines (putrescine, spermidine and spermine) play an essential role
in cell growth, differentiation and apoptosis. Hypertrophy is accompanied by an increase in …

Difluoromethylornithine attenuates isoproterenol‑induced cardiac hypertrophy by regulating apoptosis, autophagy and the mitochondria‑associated membranes …

Y Zhao, WW Jia, S Ren, W Xiao… - Experimental and …, 2021 - spandidos-publications.com
Myocardial hypertrophy is an independent risk factor of cardiovascular diseases and is
closely associated with the incidence of heart failure. In the present study, we hypothesized …

RNA-seq reveals protective mechanisms of Mongolian medicine molor-dabos-4 on acute indomethacin-induced gastric ulcers in rats

T Bao, L Feng, S Cho, H Yu, W Jin, L Dai, J Zhang… - Genes, 2022 - mdpi.com
This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects
healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the …

[HTML][HTML] Endoplasmic reticulum stress is involved in DFMO attenuating isoproterenol-induced cardiac hypertrophy in rats

Y Lin, X Zhang, W Xiao, B Li, J Wang, L Jin… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Studies performed in experimental animals have shown that polyamines
contribute to several physiological and pathological processes, including cardiac …

Evodiamine inhibits angiotensin II-induced rat cardiomyocyte hypertrophy

N He, Q Gong, F Zhang, J Zhang, S Lin, H Hou… - Chinese journal of …, 2018 - Springer
Objective To investigate the effects of evodiamine (Evo), a component of Evodiaminedia
rutaecarpa (Juss.) Benth, on cardiomyocyte hypertrophy induced by angiotensin II (Ang II) …

[HTML][HTML] Isosteviol prevents the prolongation of action potential in hypertrophied cardiomyoctyes by regulating transient outward potassium and L-type calcium …

Z Fan, N Lv, X Luo, W Tan - Biochimica et Biophysica Acta (BBA) …, 2017 - Elsevier
Cardiac hypertrophy is a thickening of the heart muscle that is associated with
cardiovascular diseases such as hypertension and myocardial infarction. It occurs initially as …

[HTML][HTML] An angiotensin receptor blocker prevents arrhythmogenic left atrial remodeling in a rat post myocardial infarction induced heart failure model

HS Kim, CW No, SH Goo, TJ Cha - Journal of Korean Medical …, 2013 - ncbi.nlm.nih.gov
This study investigated the role of angiotensin II receptor blocker in atrial remodeling in rats
with atrial fibrillation (AF) induced by a myocardial infarction (MI). MIs were induced by a …

Urea cycle disorders

NA Mew, MB Pappa, AL Gropman - … and genetic basis of neurological and …, 2015 - Elsevier
The urea cycle is the primary biochemical pathway in humans by which excess nitrogen is
disposed. Through the coordinated function of six enzymes and two mitochondrial …

Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats

N Gupta, H Zhang, P Liu - Pharmacology Biochemistry and Behavior, 2012 - Elsevier
Recent evidence suggests that polyamines putrescine, spermidine and spermine are
essential in maintaining normal cellular function. The present study investigated the effects …