Abstract l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via
ornithine decarboxylase (ODC). Polyamines plays a key role in the proliferation of intestinal …

Background/Aim: Polyamines (putrescine, spermidine and spermine) play an essential role
in cell growth, differentiation and apoptosis. Hypertrophy is accompanied by an increase in …

Myocardial hypertrophy is an independent risk factor of cardiovascular diseases and is
closely associated with the incidence of heart failure. In the present study, we hypothesized …

This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects
healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the …

Background/Aims: Studies performed in experimental animals have shown that polyamines
contribute to several physiological and pathological processes, including cardiac …

Objective To investigate the effects of evodiamine (Evo), a component of Evodiaminedia
rutaecarpa (Juss.) Benth, on cardiomyocyte hypertrophy induced by angiotensin II (Ang II) …

Cardiac hypertrophy is a thickening of the heart muscle that is associated with
cardiovascular diseases such as hypertension and myocardial infarction. It occurs initially as …

This study investigated the role of angiotensin II receptor blocker in atrial remodeling in rats
with atrial fibrillation (AF) induced by a myocardial infarction (MI). MIs were induced by a …

The urea cycle is the primary biochemical pathway in humans by which excess nitrogen is
disposed. Through the coordinated function of six enzymes and two mitochondrial …

Recent evidence suggests that polyamines putrescine, spermidine and spermine are
essential in maintaining normal cellular function. The present study investigated the effects …