Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …

Plant intra-individual and inter-individual variation can be determined by the epigenome, a
set of covalent modifications of DNA and chromatin that can alter genome structure and …

Chromatin landscapes are disrupted during DNA replication and must be restored faithfully
to maintain genome regulation and cell identity. The histone H3-H4 modification landscape …

In eukaryotes, repetitive DNA sequences are transcriptionally silenced through histone H3
lysine 9 trimethylation (H3K9me3). Loss of silencing of the repeat elements leads to genome …

Faithful inheritance of parental histones is essential to maintain epigenetic information and
cellular identity during cell division. Parental histones are evenly deposited onto the …

DNA replication produces a global disorganization of chromatin structure that takes hours to
be restored. However, how these chromatin rearrangements affect the regulation of gene …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Eukaryotic transcription occurs on chromatin, where RNA polymerase II encounters
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …