Traumatic brain injury: progress and challenges in prevention, clinical care, and research
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
Mental health consequences of traumatic brain injury
Traumatic brain injury (TBI) is associated with a host of psychiatric and neurobehavioral
problems. As mortality rates have declined for severe TBI, attention has turned to the …
problems. As mortality rates have declined for severe TBI, attention has turned to the …
Traumatic brain injury as a chronic disease: insights from the United States traumatic brain injury model systems research program
K Dams-O'Connor, SB Juengst, J Bogner… - The Lancet …, 2023 - thelancet.com
Traumatic brain injury (TBI) is a global health priority, associated with substantial burden.
Historically conceptualised as an injury event with finite recovery, TBI is now recognised as …
Historically conceptualised as an injury event with finite recovery, TBI is now recognised as …
COVID-19 and Long COVID: disruption of the neurovascular unit, blood-brain barrier, and tight junctions
D Kempuraj, KK Aenlle, J Cohen… - The …, 2023 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …
How the immune system shapes neurodegenerative diseases
HD Mason, DB McGavern - Trends in neurosciences, 2022 - cell.com
Neurodegenerative diseases are a major cause of death and disability worldwide and are
influenced by many factors including age, genetics, and injuries. While these diseases are …
influenced by many factors including age, genetics, and injuries. While these diseases are …
Extracellular vesicles derived from neural stem cells, astrocytes, and microglia as therapeutics for easing TBI-induced brain dysfunction
C Hering, AK Shetty - Stem cells translational medicine, 2023 - academic.oup.com
Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs),
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …
TGF-β as a key modulator of astrocyte reactivity: disease relevance and therapeutic implications
J Luo - Biomedicines, 2022 - mdpi.com
Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …
brain injury and disease through a process referred to as reactive astrogliosis, where the …
From neurodevelopmental to neurodegenerative disorders: the vascular continuum
J Ouellette, B Lacoste - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …
development and function, as well as healthy aging. The inability of the brain to store energy …
Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma …
The glymphatic system is a perivascular fluid clearance system, most active during sleep,
considered important for clearing the brain of waste products and toxins. Glymphatic failure …
considered important for clearing the brain of waste products and toxins. Glymphatic failure …
Influence of the neuroprotective properties of quercetin on regeneration and functional recovery of the nervous system
SOM Fideles, A de Cássia Ortiz, DV Buchaim… - Antioxidants, 2023 - mdpi.com
Quercetin is a dietary flavonoid present in vegetables, fruits, and beverages, such as onions,
apples, broccoli, berries, citrus fruits, tea, and red wine. Flavonoids have antioxidant and anti …
apples, broccoli, berries, citrus fruits, tea, and red wine. Flavonoids have antioxidant and anti …