Chagas disease in the United States: a public health approach

C Bern, LA Messenger, JD Whitman… - Clinical microbiology …, 2019 - Am Soc Microbiol
Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by
triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal …

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications

B Zingales, MA Miles, DA Campbell… - Infection, genetics and …, 2012 - Elsevier
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …

Trypanosoma cruzi and Chagas' disease in the United States

C Bern, S Kjos, MJ Yabsley… - Clinical microbiology …, 2011 - Am Soc Microbiol
Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi and causes
potentially life-threatening disease of the heart and gastrointestinal tract. The southern half …

Socioecological vulnerability and the risk of zoonotic disease emergence in Brazil

GR Winck, RLG Raimundo, H Fernandes-Ferreira… - Science …, 2022 - science.org
In developing countries, outbreaks of zoonotic diseases (ZDs) result from intertwined
ecological, socioeconomic, and demographic processes that shape conditions for (i) …

[HTML][HTML] Over Six Thousand Trypanosoma cruzi Strains Classified into Discrete Typing Units (DTUs): Attempt at an Inventory

SF Brenière, E Waleckx, C Barnabé - PLoS neglected tropical …, 2016 - journals.plos.org
Trypanosoma cruzi, the causative agent of Chagas disease, presents wide genetic diversity.
Currently, six discrete typing units (DTUs), named TcI to TcVI, and a seventh one called …

Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Pathogenesis of chagas' disease: parasite persistence and autoimmunity

ARL Teixeira, MM Hecht, MC Guimaro… - Clinical microbiology …, 2011 - Am Soc Microbiol
Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected
individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast …

Genetic diversity of Trypanosoma cruzi in bats, and multilocus phylogenetic and phylogeographical analyses supporting Tcbat as an independent DTU (discrete …

L Lima, O Espinosa-Álvarez, PA Ortiz, JA Trejo-Varón… - Acta tropica, 2015 - Elsevier
Trypanosoma cruzi is a complex of phenotypically and genetically diverse isolates
distributed in six discrete typing units (DTUs) designated as TcI–TcVI. Five years ago, T …

[HTML][HTML] Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and …

CB Moraes, MA Giardini, H Kim, CH Franco… - Scientific reports, 2014 - nature.com
Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …