Despite the growing knowledge surrounding host–microbiome interactions, we are just
beginning to understand how the gut microbiome influences—and is influenced by—host …

An emerging family of innate lymphoid cells (termed ILCs) has an essential role in the
initiation and regulation of inflammation. However, it is still unclear how ILCs are regulated …

T cell development and selection are coordinated in the thymus by a specialized niche of
diverse stromal populations,–. Although much progress has been made over the years in …

Although the function of the circulating immune cell compartment has been studied in detail
for decades, limitations in terms of access and cell yields from peripheral tissues have …

Gut microbiota constitute the largest reservoir of the human microbiome and are an
abundant and stable ecosystem—based on its diversity, complexity, redundancy, and host …

The impact of the microenvironment on innate lymphoid cell (ILC)-mediated immunity in
humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA …

The mammalian gastrointestinal tract and associated mucosal immune system harbor a
large repertoire of metabolites of prokaryotic and eukaryotic origin that play important roles …

Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the
gastrointestinal tract, with increasing prevalence, and its pathogenesis remains unclear …

Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …

Highlights•In utero microbial stimulation modulates both prenatal and postnatal immune cell
development.•Unique neonatal gut microenvironment allows for progressive colonization of …