Single-cell RNA sequencing (scRNA-Seq) is transforming our ability to characterize cells,
particularly rare cells that are often overlooked in bulk population analytical approaches …

Early-life cues shape the immune system during adulthood. However, early-life signaling
pathways and their temporal functions are not well understood. Herein, we demonstrate that …

Innate lymphoid cells (ILCs) are a group of innate lymphocytes that do not express RAG-
dependent rearranged antigen-specific cell surface receptors. ILCs are classified into five …

Invariant natural killer T (iNKT), mucosal-associated invariant T (MAIT), and γδ T cells are
innate T cells that acquire memory phenotype in the thymus and share similar biological …

Group 3 innate lymphoid cells (ILC3s) are crucial for the maintenance of host–microbiota
homeostasis in gastrointestinal mucosal tissues. The mechanisms that maintain lineage …

Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs
coordinate early eradication of pathogens and contribute to tissue healing and remodeling …

Animals are obliged to develop a relationship with the microbes that live on their surfaces.
The enormous and diverse population of microorganisms living on the skin and within the …

Epigenetic landscapes can provide insight into regulation of gene expression and cellular
diversity. Here, we examined the transcriptional and epigenetic profiles of seven human …

The epithelial lining of the gastrointestinal tract serves as the interface for digestion and
absorption of nutrients and water and as a defensive barrier. The defensive functions of the …

Microbial exposure during development can elicit long-lasting effects on the health of an
individual. However, how microbial exposure in early life leads to permanent changes in the …