Background Growing evidence has shown that genetic or epigenetic alterations are highly
involved in the initiation and progression of renal cell carcinoma (RCC). This study aimed to …

Background Comprehensive genomic profiling (CGP) with next-generation sequencing
detects genetic alterations of hundreds of genes simultaneously and multiple molecular …

The lack of sensitive and specific biomarkers for ovarian cancer leads to late stage
diagnosis of the disease in a majority of the cases. Mutation accumulation is the basis for …

Combinatorial therapies are required to treat patients with advanced cancers that have
become resistant to monotherapies through rewiring of redundant pathways. Due to a …

Background While recent studies have separately explored mutational signatures and the
tumor microenvironment (TME), there is limited research on the associations of both factors …

Cancer genomes accumulate a large number of somatic mutations resulting from
imperfection of DNA processing during normal cell cycle as well as from carcinogenic …

Distinct mutation signatures arise from environmental exposures and/or from defects in
metabolic pathways that promote genome stability. The presence of a particular mutation …

A variety of mutational processes drive cancer development, but their dynamics across the
entire disease spectrum from pre-cancerous to advanced neoplasia are poorly understood …

Over the past decade, a promising line of cancer research has utilized machine learning to
mine statistical patterns of mutations in cancer genomes for information. Recent work shows …

Simple Summary Mutational signatures due to DNA mismatch repair deficiency (dMMR) is
common in many cancers. However, the prognostic value of dMMR-associated mutational …