Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review
Dihydropyrimidines are the most important heterocyclic ring systems which play an
important role in the synthesis of DNA and RNA. Synthetically they were synthesized using …
important role in the synthesis of DNA and RNA. Synthetically they were synthesized using …
Dihydropyrimidinones scaffold as a promising nucleus for synthetic profile and various therapeutic targets: A Review
Background: This review elaborates the updated synthetic and pharmacological approaches
of a known group of dihydropyrimidinones/thiones from the multi-component reaction like …
of a known group of dihydropyrimidinones/thiones from the multi-component reaction like …
Promotional Synergistic Effect of Cs–Au NPs on the Performance of Cs–Au/MgFe2O4 Catalysts in Catalysis 3,4-Dihydropyrimidin-2(1H)-Ones and Degradation of …
The recent paper deals with the immobilization of hybrid gold–cesium nanoparticles (Au–Cs
NPs) onto magnesium ferrites (MgFe2O4) surface, and then the prepared composites were …
NPs) onto magnesium ferrites (MgFe2O4) surface, and then the prepared composites were …
Unexpected products using Biginelli reaction: Synthesis, antimicrobial potency, docking simulation, and DFT investigations of some new amidopyridines
The Biginelli reaction of 3-oxo-N-(2-pyridyl) butanamide with thiourea (or urea) and some
aromatic aldehydes afforded new chemical skeletons containing tetrahydropyrimidine …
aromatic aldehydes afforded new chemical skeletons containing tetrahydropyrimidine …
A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …
S Faizan, TF Roohi, RM Raju, S Yuvaraj… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …
They are widely used in a variety of pharmacological and industrial applications. Their …
Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors
An operationally simple Biginelli protocol was employed for the synthesis of new C6-carbon
based aryl α-haloacrylamide-linked dihydropyrimidinone derivatives. The synthesized …
based aryl α-haloacrylamide-linked dihydropyrimidinone derivatives. The synthesized …
[HTML][HTML] Progress in HIV-1 integrase inhibitors: A review of their chemical structure diversity
Z Hajimahdi, A Zarghi - Iranian journal of pharmaceutical research …, 2016 - ncbi.nlm.nih.gov
Abstract HIV-1 integrase (IN) enzyme, one of the three main enzymes of HIV-1, catalyzed the
insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue …
insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue …
Synthesis and anticancer activity of new dihydropyrimidinone derivatives
AS Mostafa, KB Selim - European journal of medicinal chemistry, 2018 - Elsevier
A series of dihydropyrimidinone derivatives bearing various N-heterocyclic moieties was
designed and synthesized. Twelve new compounds were screened for their cytotoxic activity …
designed and synthesized. Twelve new compounds were screened for their cytotoxic activity …
Structural biology of HIV integrase strand transfer inhibitors
Integrase (IN) strand transfer inhibitors (INSTIs) are recent compounds in the antiretroviral
arsenal used against HIV. INSTIs work by blocking retroviral integration; an essential step in …
arsenal used against HIV. INSTIs work by blocking retroviral integration; an essential step in …
A new class of half-sandwich ruthenium complexes containing Biginelli hybrids: Anticancer and anti-SARS-CoV-2 activities
N Janković, E Milović, JĐ Jovanović, Z Marković… - Chemico-Biological …, 2022 - Elsevier
In order to discover new dual-active agents, a series of novel Biginelli hybrids
(tetrahydropyrimidines) and their ruthenium (II) complexes were synthesized. Newly …
(tetrahydropyrimidines) and their ruthenium (II) complexes were synthesized. Newly …