The therapeutic efficacy of orally administered drugs is often restricted by their inherent
limited oral bioavailability. Low water solubility, limited permeability through the intestinal …

A large proportion of new chemical moieties are poorly water-soluble. As a result, the
biggest challenge for researchers is to enhance the solubility and oral bioavailability of …

Alectinib hydrochloride (ALH), a tyrosine kinase inhibitor, is a practically water-insoluble
drug classified as BCS class IV. The present study aimed to develop novel suspended self …

In this study, a solidified self-nanoemulsifying drug delivery system (solidified SNEDDS) and
surface-modified microspheres were developed for enhancing the oral bioavailability of …

The self-generating nano-emulsifying drug delivery system (SNEDDS) is among the most
effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of …

Disodium pamidronate, a second-generation bisphosphonate is a potent drug for the
treatment of osteoporosis, which has been very well established by previous literature. It has …

Self-emulsifying drug delivery system (SEDDS), a category of lipid-based technology, has
gained interest in the recent years for enhancement of solubility and bioavailability of poorly …

Salmonella Typhi is an intracellular bacterium causing a variety of enteric diseases, being
typhoid fever the most common. Current modalities for treating S. typhi infection are …

This study compares rivaroxaban-loaded polymeric microsphere systems with three types of
surface microstructure. Three types of polymeric microspheres loaded with rivaroxaban were …

According to the WHO, cancer caused almost 10 million deaths worldwide in 2020, ie,
almost one in six deaths. Among the most common are breast, lung, colon and rectal and …