Clonal hematopoiesis of indeterminate potential predicts adverse outcomes in patients with atherosclerotic cardiovascular disease
Background Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal
expansion of blood stem cells with leukemia-associated mutations—is a novel …
expansion of blood stem cells with leukemia-associated mutations—is a novel …
Clinical and Therapeutic Implications of Clonal Hematopoiesis
G Petrone, I Turker, P Natarajan… - Annual Review of …, 2024 - annualreviews.org
Clonal hematopoiesis (CH) is an age-related process whereby hematopoietic stem and
progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal …
progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal …
Germline Predisposition for Clonal Hematopoiesis
Clonal hematopoiesis (CH) is an entity hallmarked by skewed hematopoiesis with persistent
overrepresentation of cells from a common stem/progenitor lineage harboring single …
overrepresentation of cells from a common stem/progenitor lineage harboring single …
Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias
Abstract Background and Aims Clonal haematopoiesis of indeterminate potential (CHIP), the
age-related expansion of blood cells with preleukemic mutations, is associated with …
age-related expansion of blood cells with preleukemic mutations, is associated with …
Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis
Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …
Birth weight is associated with clonal hematopoiesis of indeterminate potential and cardiovascular outcomes in adulthood
Background High and low birth weight are independently associated with increased
cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential …
cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential …
Body‐wide chimerism and mosaicism are predominant causes of naturally occurring ABO discrepancies
EM Dauber, OA Haas, K Nebral… - British Journal of …, 2024 - Wiley Online Library
Routine ABO blood group typing of apparently healthy individuals sporadically uncovers
unexplained mixed‐field reactions. Such blood group discrepancies can either result from a …
unexplained mixed‐field reactions. Such blood group discrepancies can either result from a …
[HTML][HTML] Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis
MM Uddin, S Saadatagah, A Niroula, B Yu, W Hornsby… - medRxiv, 2023 - ncbi.nlm.nih.gov
Clonal hematopoiesis (CH), characterized by blood cells predominantly originating from a
single mutated hematopoietic stem cell, is linked to diverse aging-related diseases …
single mutated hematopoietic stem cell, is linked to diverse aging-related diseases …
Germline genetic variants that predispose to myeloproliferative neoplasms and hereditary myeloproliferative phenotypes
Epidemiological evidence of familial predispositions to myeloid malignancies and
myeloproliferative neoplasms (MPN) has long been recognized, but recent studies have …
myeloproliferative neoplasms (MPN) has long been recognized, but recent studies have …
Multi-ancestry genome-wide association meta-analysis of mosaic loss of chromosome Y in the Million Veteran Program identifies 167 novel loci
Mosaic loss of chromosome Y (mLOY) is a common somatic mutation in leukocytes of older
males. mLOY was detected in 126,108 participants of the Million Veteran Program: 106,054 …
males. mLOY was detected in 126,108 participants of the Million Veteran Program: 106,054 …