[HTML][HTML] Cyclodextrins: Structural, chemical, and physical properties, and applications

BG Poulson, QA Alsulami, A Sharfalddin… - Polysaccharides, 2021 - mdpi.com
Due to their unique structural, physical and chemical properties, cyclodextrins and their
derivatives have been of great interest to scientists and researchers in both academia and …

Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs

KU Khan, MU Minhas, SF Badshah, M Suhail, A Ahmad… - Life Sciences, 2022 - Elsevier
Poor aqueous solubility and poor bioavailability are major issues with many pharmaceutical
industries. By some estimation, 70–90% drug candidates in development stage while up-to …

[HTML][HTML] Intestinal absorption study: Challenges and absorption enhancement strategies in improving oral drug delivery

M Azman, AH Sabri, QK Anjani, MF Mustaffa… - Pharmaceuticals, 2022 - mdpi.com
The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

[HTML][HTML] Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

P Khadka, J Ro, H Kim, I Kim, JT Kim, H Kim… - Asian journal of …, 2014 - Elsevier
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug
compounds that limits in vivo bioavailability owing to their low dissolution rate in the …

Cyclodextrins as encapsulation agents for plant bioactive compounds

E Pinho, M Grootveld, G Soares, M Henriques - Carbohydrate polymers, 2014 - Elsevier
Plants possess a wide range of molecules capable of improve healing: fibre, vitamins,
phytosterols, and further sulphur-containing compounds, carotenoids, organic acid anions …

A comprehensive review on contact lens for ophthalmic drug delivery

J Xu, Y Xue, G Hu, T Lin, J Gou, T Yin, H He… - Journal of controlled …, 2018 - Elsevier
With the prevalence of electronic devices and an aging population, the number of people
affected with eye disease is increasing year by year. In spite of a large number of eye drops …

Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance

M Creixell, NA Peppas - Nano today, 2012 - Elsevier
There are two main mechanisms by which cells become multidrug resistant (MDR): by
increasing drug efflux pumps on the cell membrane and by increasing anti-apoptotic …

Nanosponges: A novel class of drug delivery system-review

S Selvamuthukumar, S Anandam… - … of Pharmacy & …, 2012 - journals.library.ualberta.ca
Effective targeted drug delivery systems have been a dream for a long time, but it has been
largely frustrated by the complex chemistry that is involved in the development of new …

Exploring versatile applications of cyclodextrins: an overview

N Sharma, A Baldi - Drug delivery, 2016 - Taylor & Francis
Context: Ever since the discovery of cyclodextrins, a family of cyclic oligosaccharides based
on α (1→ 4) linkage among glucopyranose subunits, these versatile supramolecular hosts …

[HTML][HTML] Cyclodextrin inclusion complexes for improved drug bioavailability and activity: synthetic and analytical aspects

Á Sarabia-Vallejo, MM Caja, AI Olives, MA Martín… - Pharmaceutics, 2023 - mdpi.com
Many active pharmaceutical ingredients show low oral bioavailability due to factors such as
poor solubility and physical and chemical instability. The formation of inclusion complexes …