A drug delivery system is defined as a formulation or a device that enables the introduction
of a therapeutic substance into the body and improves its efficacy and safety by controlling …

Oral absorption of compounds depends on many physiological, physiochemical and
formulation factors. Two important properties that govern oral absorption are in vitro …

Glipizide (GLZ) is an oral hypoglycemic agent, which is a weakly aqueous soluble drug. The
solubility values of GLZ in various neat solvents are scarce in the literature. Hence, the …

As discussed in previous chapters, significant advances have been attained in developing
and commercializing oral controlled release products. Many platforms are available for …

Enhancement of solubility and dissolution of glipizide by solid dispersion (kneading)
technique Page 1 245 Asian Journal of Pharmaceutics - July-September 2009 …

Glipizide, a poor water-soluble drug belongs to BCS class II. The proposed work aimed to
enhance the solubility of glipizide by preparing solid dispersions, using polyvinyl pyrrolidone …

Glimepiride (GMP) is third Generation sulphonyl ureas used for treatment of type 2 diabetes.
Poor water solubility is the main constant for its oral bioavailability. The rationale of this study …

A non-ionic amorphous active API ((RR)-3 ((1R)-3-oxocyclopentyl)-2-[3-chloro-4-methyl
sulfonyl] phenyl-N-pyrozin-2ylpropanamide) with a glass transition temperature of 60° C and …

Elementary osmotic pumps are well known for delivering moderately soluble drugs at a zero-
order rate. The objective of the present study was to develop elementary osmotic pump …

Purpose: To develop controlled release osmotic pump tablets (COPT) of glipizide (GZ) solid
dispersion (SD). Methods: In elementary osmotic pump (EOP) tablets, an osmotic core with …