The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Targeting epigenetic regulators to overcome drug resistance in cancers

N Wang, T Ma, B Yu - Signal transduction and targeted therapy, 2023 - nature.com
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression

H Liu, D Li, L Sun, H Qin, A Fan, L Meng… - Molecular cancer, 2022 - Springer
Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis
and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously …

Steps in metastasis: an updated review

J Majidpoor, K Mortezaee - Medical Oncology, 2021 - Springer
Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …

Noncoding RNAs in gastric cancer: implications for drug resistance

L Wei, J Sun, N Zhang, Y Zheng, X Wang, L Lv, J Liu… - Molecular cancer, 2020 - Springer
Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-
related deaths worldwide. Advanced gastric cancer patients can notably benefit from …

lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions

EM McCabe, TP Rasmussen - Seminars in cancer biology, 2021 - Elsevier
Epithelial to mesenchymal transition (EMT) is a cellular process in which cells composing
epithelial tissue lose requirements for physical contact with neighboring cells and acquire …

Context-dependent EMT programs in cancer metastasis

NM Aiello, Y Kang - Journal of Experimental Medicine, 2019 - rupress.org
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …

Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation

Y Luo, S Zheng, Q Wu, J Wu, R Zhou, C Wang, Z Wu… - Autophagy, 2021 - Taylor & Francis
Chemotherapy is currently the main treatment for unresectable or advanced postoperative
gastric cancers. However, its efficacy is negatively affected by the occurrence of …

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

SY Lee, EK Jeong, MK Ju, HM Jeon, MY Kim, CH Kim… - Molecular cancer, 2017 - Springer
Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets

M Klingenberg, A Matsuda, S Diederichs, T Patel - Journal of hepatology, 2017 - Elsevier
The majority of the human genome is not translated into proteins but can be transcribed into
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …