The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …
development and tissue regeneration. However, aberrant reactivation of EMT is associated …
Targeting epigenetic regulators to overcome drug resistance in cancers
N Wang, T Ma, B Yu - Signal transduction and targeted therapy, 2023 - nature.com
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …
regulation is a heritable change in gene expressions independent of nucleotide sequence …
Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression
H Liu, D Li, L Sun, H Qin, A Fan, L Meng… - Molecular cancer, 2022 - Springer
Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis
and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously …
and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously …
Steps in metastasis: an updated review
J Majidpoor, K Mortezaee - Medical Oncology, 2021 - Springer
Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …
Noncoding RNAs in gastric cancer: implications for drug resistance
L Wei, J Sun, N Zhang, Y Zheng, X Wang, L Lv, J Liu… - Molecular cancer, 2020 - Springer
Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-
related deaths worldwide. Advanced gastric cancer patients can notably benefit from …
related deaths worldwide. Advanced gastric cancer patients can notably benefit from …
lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions
EM McCabe, TP Rasmussen - Seminars in cancer biology, 2021 - Elsevier
Epithelial to mesenchymal transition (EMT) is a cellular process in which cells composing
epithelial tissue lose requirements for physical contact with neighboring cells and acquire …
epithelial tissue lose requirements for physical contact with neighboring cells and acquire …
Context-dependent EMT programs in cancer metastasis
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …
Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation
Y Luo, S Zheng, Q Wu, J Wu, R Zhou, C Wang, Z Wu… - Autophagy, 2021 - Taylor & Francis
Chemotherapy is currently the main treatment for unresectable or advanced postoperative
gastric cancers. However, its efficacy is negatively affected by the occurrence of …
gastric cancers. However, its efficacy is negatively affected by the occurrence of …
Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation
SY Lee, EK Jeong, MK Ju, HM Jeon, MY Kim, CH Kim… - Molecular cancer, 2017 - Springer
Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …
Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets
M Klingenberg, A Matsuda, S Diederichs, T Patel - Journal of hepatology, 2017 - Elsevier
The majority of the human genome is not translated into proteins but can be transcribed into
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …