The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …

Whole genome sequencing (WGS) shows promise as a first-tier diagnostic test for patients
with rare genetic disorders. However, standards addressing the definition and deployment …

Importance Clonal hematopoiesis of indeterminate potential (CHIP) is associated with
increased risk of atherosclerotic cardiovascular disease, and mouse experiments suggest …

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

The use of blood liquid biopsy is being gradually incorporated into the clinical setting of
cancer management. The minimally invasive nature of the usage of cell-free DNA (cfDNA) …

People with human immunodeficiency virus (HIV) have higher rates of certain comorbidities,
particularly cardiovascular disease and cancer, than people without HIV,,,–. In view of …

Clonal hematopoiesis (CH) is an age-related condition predisposing to blood cancer and
cardiovascular disease (CVD). Murine models demonstrate CH-mediated altered immune …

Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal
outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of …

Stably acquired mutations in hematopoietic cells represent substrates of selection that may
lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with …

Importance A total of 1% to 3% of patients treated with a poly (adenosine diphosphate–
ribose) polymerase inhibitor for high-grade ovarian cancer (HGOC) develop therapy-related …