Background Peripheral brain-derived neurotrophic factor (BDNF) is decreased in acute
major depressive disorder (MDD) and bipolar disorder (BD) and recovered after treatment …

The efficacy of ketamine in reducing suicidal ideation (SI) has been previously reported. We
aimed to evaluate acute anti-SI effects of single-dose ketamine in different …

Transcranial direct current stimulation (tDCS) is a non-invasive method for brain stimulation.
Although pilot trials have shown that tDCS yields promising results for major depressive …

The purpose of the present study was to investigate whether ketamine's rapid
antidepressant effects were associated with its anti-inflammatory actions and to explore the …

The selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
pharmacological treatment for depression. Since their introduction many have considered …

Background Depressed patients presenting to emergency departments with acute suicidal
ideation are a major public health concern. Ketamine, a rapidly acting antidepressant with …

Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …

Objective Previous studies investigated predictors of repetitive transcranial magnetic
stimulation (rTMS) response in depressive disorders but there is still limited knowledge …

Objective: High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is a safe
and effective treatment for major depression. However, its utility as a strategy to accelerate …

Rapastinel as the allosteric modulator of N-methyl-D-aspartate receptor (NMDAR) produces
rapid antidepressant-like effects dependent on brain-derived neurotrophic factor (BDNF) …