Review on the computational genome annotation of sequences obtained by next-generation sequencing

GF Ejigu, J Jung - Biology, 2020 - mdpi.com
Simple Summary Due to the development of high-throughput sequencing technologies,
computational genome annotation of sequences has become one of the principal research …

PVT1: a rising star among oncogenic long noncoding RNAs

T Colombo, L Farina, G Macino… - BioMed research …, 2015 - Wiley Online Library
It is becoming increasingly clear that short and long noncoding RNAs critically participate in
the regulation of cell growth, differentiation, and (mis) function. However, while the functional …

The EMBL-EBI bioinformatics web and programmatic tools framework

W Li, A Cowley, M Uludag, T Gur… - Nucleic acids …, 2015 - academic.oup.com
Abstract Since 2009 the EMBL-EBI Job Dispatcher framework has provided free access to a
range of mainstream sequence analysis applications. These include sequence similarity …

MG-RAST, a metagenomics service for analysis of microbial community structure and function

KP Keegan, EM Glass, F Meyer - Microbial environmental genomics (MEG), 2016 - Springer
Approaches in molecular biology, particularly those that deal with high-throughput
sequencing of entire microbial communities (the field of metagenomics), are rapidly …

NCBI viral genomes resource

JR Brister, D Ako-Adjei, Y Bao… - Nucleic acids …, 2015 - academic.oup.com
Recent technological innovations have ignited an explosion in virus genome sequencing
that promises to fundamentally alter our understanding of viral biology and profoundly …

Long noncoding RNAs in cancer: from discovery to therapeutic targets

R Choudhari, MJ Sedano, AL Harrison… - Advances in clinical …, 2020 - Elsevier
Long noncoding RNAs (lncRNAs) have recently gained considerable attention as key
players in biological regulation; however, the mechanisms by which lncRNAs govern …

The European Bioinformatics Institute in 2016: data growth and integration

CE Cook, MT Bergman, RD Finn… - Nucleic acids …, 2016 - academic.oup.com
New technologies are revolutionising biological research and its applications by making it
easier and cheaper to generate ever-greater volumes and types of data. In response, the …

DeepDSC: a deep learning method to predict drug sensitivity of cancer cell lines

M Li, Y Wang, R Zheng, X Shi, Y Li… - … /ACM transactions on …, 2019 - ieeexplore.ieee.org
High-throughput screening technologies have provided a large amount of drug sensitivity
data for a panel of cancer cell lines and hundreds of compounds. Computational …

Problems, challenges and promises: perspectives on precision medicine

DJ Duffy - Briefings in bioinformatics, 2016 - academic.oup.com
The 'precision medicine (systems medicine)'concept promises to achieve a shift to future
healthcare systems with a more proactive and predictive approach to medicine, where the …

Biological databases for human research

D Zou, L Ma, J Yu, Z Zhang - Genomics, proteomics and …, 2015 - academic.oup.com
The completion of the Human Genome Project lays a foundation for systematically studying
the human genome from evolutionary history to precision medicine against diseases. With …