Work performed with differentiated contractile smooth muscle tissue over the last two
decades has made clear that covalent modification of myosin by phosphorylation of the 20 …

Actin-activated myosin II motor function powers muscle contraction and nonmuscle cell
motility. The actin-myosin-derived contractility has evolved with a great diversity in different …

Polymerized (F-) actin is induced to form bundles by a number of polycations including
divalent metal ions, Co (NH), and basic polypeptides. The general features of bundle …

The Arp2/3 complex, first isolated from Acanthamoeba castellani by affinity chromatography
on profilin, consists of seven polypeptides; two actinrelated proteins, Arp2 and Arp3; and five …

The vasodilator‐stimulated phosphoprotein (VASP) colocalizes with the ends of stress fibers
in cell‐matrix and cell‐cell contacts. We report here that bacterially expressed murine VASP …

Smooth muscle contraction is regulated primarily by the reversible phosphorylation of
myosin triggered by an increase in sarcoplasmic free Ca2+ concentration ([Ca2+] i) …

Calponins and transgelins are members of a conserved family of actin-associated proteins
widely expressed from yeast to humans. Although a role for calponin in muscle cells has …

The association of F-actin (filamentous actin) with a large number of binding proteins is
essential for cellular function. Actin-binding proteins control the dynamics of actin filaments …

Calponin is a troponin-T like protein purified from chicken gizzard smooth muscle. It binds to
actin, myosin, Ca2+-binding proteins and tropomyosin and inhibits the actomyosin ATPase …

Previous studies from this laboratory have shown that, upon agonist activation, calponin co-
immunoprecipitates and co-localizes with protein kinase Cε (PKCε) in vascular smooth …