The prognostic value of natural killer cells and their receptors/ligands in hepatocellular carcinoma: a systematic review and meta-analysis

JS Xue, ZN Ding, GX Meng, LJ Yan, H Liu… - Frontiers in …, 2022 - frontiersin.org
Background Natural killer (NK) cells play major roles in eliminating tumor cells. Preliminary
studies have shown that NK cells and their receptors/ligands have prognostic value in …

The soldiers needed to be awakened: Tumor-infiltrating immune cells

W Yaping, W Zhe, C Zhuling, L Ruolei, F Pengyu… - Frontiers in …, 2022 - frontiersin.org
In the tumor microenvironment, tumor-infiltrating immune cells (TIICs) are a key component.
Different types of TIICs play distinct roles. CD8+ T cells and natural killer (NK) cells could …

Multiomics profiling of buffy coat and plasma unveils etiology-specific signatures in hepatocellular carcinoma

J Hong, JW Eun, GO Baek, JY Cheong, S Park… - Clinical and Molecular …, 2024 - e-cmh.org
Methods We generated whole-transcriptome sequencing (WTS) and targeted proteome data
from buffy coat and plasma samples from HCC patients. By integrating etiological …

Prediction of Prognosis and Immunotherapy Response with a Novel Natural Killer Cell Marker Genes Signature in Osteosarcoma

Q Li, X Huang, Y Zhao - Cancer Biotherapy & Radiopharmaceuticals, 2023 - liebertpub.com
Background: Natural killer (NK) cells are characterized by their antitumor efficacy without
previous sensitization, which have attracted attention in tumor immunotherapy. The …

[HTML][HTML] Dampening of cytotoxic innate lymphoid cells: A new tumour immune escape mechanism in B cell non-Hodgkin's lymphoma

S Roma, C Camisaschi, P Mancuso, S Trabanelli… - Cellular …, 2022 - Elsevier
The role and regulation of innate immune cells is poorly understood in B-cell non-Hodgkin
lymphoma (NHL). As natural killer (NK) cells, helper innate lymphoid cells (ILCs) are …

Heterogeneity of group 2 innate lymphoid cells defines their pleiotropic roles in cancer, obesity, and cardiovascular diseases

M Ikutani, S Nakae - Frontiers in immunology, 2022 - frontiersin.org
Group 2 innate lymphoid cells (ILC2s) are typically known for their ability to respond rapidly
to parasitic infections and play a pivotal role in the development of certain allergic disorders …

Single-cell RNA sequencing to explore composition of peripheral blood NK cells in patients with chronic myeloid leukemia in treatment-free remission

G Yu, W Lu, X Chen, Y Li, J Long, Z Zheng… - Leukemia & …, 2022 - Taylor & Francis
This study was to explore the role of NK cell subsets and gene expression in maintaining
TFR status. We identified six types of NK cells in the PBMCs over both groups (healthy …

CAR-NK 细胞治疗血液肿瘤的研究进展

刘洪秀, 韩艳秋 - 临床血液学杂志, 2023 - lcxy.whuhzzs.com
NK 细胞作为固有免疫细胞在肿瘤免疫监视中发挥重要作用. 相比CAR-T 其神经毒性,
细胞因子释放综合征等不良反应和移植物抗宿主病鲜有发生, 因此有希望成为嵌合抗原受体细胞 …

Deciphering innate immune cell-tumor microenvironment crosstalk at a single-cell level

R Sugimura, Y Chao - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The tumor microenvironment encompasses various innate immune cells which regulate
tumor progression. Exploiting innate immune cells is a new frontier of cancer …

Role and regulation of human innate lymphoid cells and natural killer cells in lymphoma

S Roma - 2021 - air.unimi.it
Innate immune system can be helpful or harmful in cancer regression depending on tumor
microenvironment. Innate lymphoid cells are constituents of innate immune system with …