Copper homeostasis and cuproptosis in health and disease

L Chen, J Min, F Wang - Signal transduction and targeted therapy, 2022 - nature.com
As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies

X Chen, Q Cai, R Liang, D Zhang, X Liu, M Zhang… - Cell death & …, 2023 - nature.com
Copper is a vital mineral, and an optimal amount of copper is required to support normal
physiologic processes in various systems, including the cardiovascular system. Over the …

Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies

X Wang, M Zhou, Y Liu, Z Si - Cancer Letters, 2023 - Elsevier
Recent studies have established a strong link between copper and cancer biology, as
copper is necessary for cancer growth and metastasis. Beyond the conventional concept of …

Mitochondrial copper in human genetic disorders

NM Garza, AB Swaminathan, KP Maremanda… - Trends in Endocrinology …, 2023 - cell.com
Copper is an essential micronutrient that serves as a cofactor for enzymes involved in
diverse physiological processes, including mitochondrial energy generation. Copper enters …

Biopolymer-assisted enzyme-induced carbonate precipitation for immobilizing Cu ions in aqueous solution and loess

YX Xie, WC Cheng, L Wang, ZF Xue, YL Xu - Environmental Science and …, 2023 - Springer
Wastewater, discharged in copper (Cu) mining and smelting, usually contains a large
amount of Cu2+. Immobilizing Cu2+ in aqueous solution and soils is deemed crucial in …

Copper homeostasis and cuproptosis in tumor pathogenesis and therapeutic strategies

C Bian, Z Zheng, J Su, S Chang, H Yu, J Bao… - Frontiers in …, 2023 - frontiersin.org
Copper is an indispensable micronutrient for the development and replication of all
eukaryotes, and its redox properties are both harmful and beneficial to cells. An imbalance …

Emerging mechanisms in the redox regulation of mitochondrial cytochrome c oxidase assembly and function

S Povea-Cabello, M Brischigliaro… - Biochemical Society …, 2024 - portlandpress.com
In eukaryotic cells, mitochondria perform cellular respiration through a series of redox
reactions ultimately reducing molecular oxygen to water. The system responsible for this …

Schizosaccharomyces pombe as a fundamental model for research on mitochondrial gene expression: Progress, achievements and outlooks

N Dinh, N Bonnefoy - IUBMB life, 2024 - Wiley Online Library
Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial
research. The organism resembles human cells in terms of mitochondrial inheritance …

BOLA3 and NFU1 link mitoribosome iron–sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome

H Zhong, A Janer, O Khalimonchuk… - Nucleic acids …, 2023 - academic.oup.com
The human mitochondrial ribosome contains three [2Fe–2S] clusters whose assembly
pathway, role, and implications for mitochondrial and metabolic diseases are unknown …

Recent advances in copper-based organic complexes and nanoparticles for tumor theranostics

S Tsymbal, G Li, N Agadzhanian, Y Sun, J Zhang… - Molecules, 2022 - mdpi.com
Treatment of drug-resistant forms of cancer requires consideration of their hallmark features,
such as abnormal cell death mechanisms or mutations in drug-responding molecular …