[HTML][HTML] Treatment of overdose in the synthetic opioid era
P Skolnick - Pharmacology & therapeutics, 2022 - Elsevier
Overdose deaths are often viewed as the leading edge of the opioid epidemic which has
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is …
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is …
[HTML][HTML] Management of pharmaceutical and recreational drug poisoning
B Mégarbane, M Oberlin, JC Alvarez, F Balen… - Annals of intensive …, 2020 - Springer
Background Poisoning is one of the leading causes of admission to the emergency
department and intensive care unit. A large number of epidemiological changes have …
department and intensive care unit. A large number of epidemiological changes have …
Noradrenergic mechanisms in fentanyl-mediated rapid death explain failure of naloxone in the opioid crisis
R Torralva, A Janowsky - Journal of Pharmacology and Experimental …, 2019 - ASPET
In December 2018, the Centers for Disease Control declared fentanyl the deadliest drug in
America. Opioid overdose is the single greatest cause of death in the United States adult …
America. Opioid overdose is the single greatest cause of death in the United States adult …
Synthetic opioids: a review and clinical update
A Shafi, AJ Berry, H Sumnall… - Therapeutic …, 2022 - journals.sagepub.com
The term 'opioids' refers to both the natural compounds ('opiates') which are extracted from
the opium poppy plant (Papaver somniferum) and their semi-synthetic and synthetic …
the opium poppy plant (Papaver somniferum) and their semi-synthetic and synthetic …
[图书][B] Novel psychoactive substances: classification, pharmacology and toxicology
PI Dargan, DM Wood - 2021 - books.google.com
Novel Psychoactive Substances: Classification, Pharmacology and Toxicology, Second
Edition provides readers with a comprehensive examination on the classification, detection …
Edition provides readers with a comprehensive examination on the classification, detection …
Combined treatment with naloxone and the alpha2 adrenoceptor antagonist atipamezole reversed brain hypoxia induced by a fentanyl-xylazine mixture in a rat model
Xylazine, a veterinary tranquillizer known by drug users as “Tranq”, is being increasingly
detected in people who overdose on opioid drugs, indicating enhanced health risk of …
detected in people who overdose on opioid drugs, indicating enhanced health risk of …
Neural basis of opioid-induced respiratory depression and its rescue
Opioid-induced respiratory depression (OIRD) causes death following an opioid overdose,
yet the neurobiological mechanisms of this process are not well understood. Here, we show …
yet the neurobiological mechanisms of this process are not well understood. Here, we show …
The pattern of brain oxygen response induced by intravenous fentanyl limits the time window of therapeutic efficacy of naloxone
CM Curay, MR Irwin, EA Kiyatkin - Neuropharmacology, 2023 - Elsevier
Opioids induce respiratory depression resulting in coma or even death during overdose.
Naloxone, an opioid antagonist, is the gold standard reversal agent for opioid intoxication …
Naloxone, an opioid antagonist, is the gold standard reversal agent for opioid intoxication …
Fentanyl causes naloxone-resistant vocal cord closure: a platform for testing opioid overdose treatments
NB Miner, WE Schutzer, Y Zarnegarnia… - Drug and alcohol …, 2021 - Elsevier
Background High doses of the synthetic opioid fentanyl cause rapid and sustained vocal
cord closure (VCC) leading to airway obstruction that prevents overdose victims from …
cord closure (VCC) leading to airway obstruction that prevents overdose victims from …
The effect of person‐first language on attitudes toward people with addiction
EA Baker, M Hamilton, D Culpepper… - Journal of addictions …, 2022 - Wiley Online Library
We examined the impact of language on addiction stigma when using postmodified nouns
versus premodified nouns. Use of postmodified nouns was associated with less …
versus premodified nouns. Use of postmodified nouns was associated with less …