Molecular physiology and pathophysiology of bilirubin handling by the blood, liver, intestine, and brain in the newborn

TWR Hansen, RJ Wong… - Physiological …, 2020 - journals.physiology.org
Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …

The role of phototherapy in the crash-cart approach to extreme neonatal jaundice

TWR Hansen - Seminars in perinatology, 2011 - Elsevier
Extreme neonatal jaundice occurs infrequently but carries a high risk of permanent sequelae
(kernicterus) when it does. Rapid therapeutic intervention has the potential to reduce this …

Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full-term infants

S Yahia, AE Shabaan, M Gouida, D El-Ghanam… - European journal of …, 2015 - Springer
Concerns of possible genotoxic effects of hyperbilirubinemia and phototherapy were raised
from experimental and observational studies in neonates. This study aimed to assess the …

[HTML][HTML] The biological effects of bilirubin photoisomers

J Jasprova, M Dal Ben, E Vianello, I Goncharova… - PLoS …, 2016 - journals.plos.org
Although phototherapy was introduced as early as 1950's, the potential biological effects of
bilirubin photoisomers (PI) generated during phototherapy remain unclear. The aim of our …

Formation of photoproducts and cytotoxicity of bilirubin irradiated with turquoise and blue phototherapy light

E Bruzell Roll, T Christensen - Acta Paediatrica, 2005 - Wiley Online Library
Aim: To compare a new turquoise (“green”) fluorescent phototherapy lamp (490 nm) with a
conventional blue phototherapy lamp (450 nm) with respect to cytotoxicity and …

[PDF][PDF] Bilirubin toxicity

D Brites, MA Brito - Care of the jaundiced neonate. New York …, 2012 - researchgate.net
For many years, unconjugated bilirubin (UCB) was thought to be a useless waste product of
heme catabolism, with no physiological function, but with potential toxicity. Toxicity resulting …

Biology of bilirubin photoisomers

TWR Hansen - Clinics in Perinatology, 2016 - perinatology.theclinics.com
Jaundice from unconjugated hyperbilirubinemia is arguably the most common reason for
diagnostic and therapeutic interventions in newborn infants. Estimates for usage rates in …

Intermittent phototherapy versus continuous phototherapy for neonatal jaundice

SB Gottimukkala, L Lobo, KS Gautham… - Cochrane Database …, 2023 - cochranelibrary.com
Background Phototherapy is a widely accepted, effective first‐line therapy for neonatal
jaundice. It is traditionally used continuously but intermittent phototherapy has been …

Apoptosis in the small intestine of neonatal rat using blue light-emitting diode devices and conventional halogen-quartz devices in phototherapy

K Tanaka, H Hashimoto, T Tachibana… - Pediatric surgery …, 2008 - Springer
Phototherapy is the most frequently used treatment for the neonatal jaundice. However,
recent papers report that phototherapy increased apoptosis in peripheral mononuclear …

[HTML][HTML] In vitro photosensitization initiated by camphorquinone and phenyl propanedione in dental polymeric materials

T Christensen, E Morisbak, HH Tønnesen… - … of Photochemistry and …, 2010 - Elsevier
Documentation is scarce on the photobiological effects of photoinitiators present in dental
light curable materials. The aim of this study was to determine cellular effects of the …