Structural and functional annotation of solute carrier transporters: implication for drug discovery

V Dvorak, G Superti-Furga - Expert Opinion on Drug Discovery, 2023 - Taylor & Francis
ABSTRACT Introduction Solute carriers (SLCs) represent the largest group of membrane
transporters in the human genome. They play a central role in controlling the …

[HTML][HTML] Endothelial GLUTs and vascular biology

WZ Wu, YP Bai - Biomedicine & pharmacotherapy, 2023 - Elsevier
Endothelial metabolism is a promising target for vascular functional regulation and disease
therapy. Glucose is the primary fuel for endothelial metabolism, supporting ATP generation …

[HTML][HTML] Tumor cell membrane-coated continuous electrochemical sensor for GLUT1 inhibitor screening

J Zhao, Y Liu, L Zhu, J Li, Y Liu, J Luo, T Xie… - Journal of …, 2023 - Elsevier
Abstract Glucose transporter 1 (GLUT1) overexpression in tumor cells is a potential target for
drug therapy, but few studies have reported screening GLUT1 inhibitors from natural or …

An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT inhibitors

MK Temre, A Kumar, SM Singh - Frontiers in Pharmacology, 2022 - frontiersin.org
Neoplastic cells displayed altered metabolism with accelerated glycolysis. Therefore, these
cells need a mammoth supply of glucose for which they display an upregulated expression …

Intelligent delivery systems in tumor metabolism regulation: exploring the path ahead

X Li, T Sun, C Jiang - Advanced Materials, 2024 - Wiley Online Library
Cancer metabolism plays multifaceted roles in the initiation and progression of tumors, and
interventions in metabolism are considered fundamental approaches for cancer control …

Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect

X Jiang, N Yan, D Deng, C Yan - IUBMB life, 2022 - Wiley Online Library
Cancer cells shift their glucose catabolism from aerobic respiration to lactic fermentation
even in the presence of oxygen, and this is known as the “Warburg effect”. To accommodate …

Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells

M Xu, W Zhong, C Yang, M Liu, X Yuan, T Lu, D Li… - Phytomedicine, 2024 - Elsevier
Background Tiliroside (TIL) is a flavonoid compound that exists in a variety of edible plants.
These dietary plants are widely used as food and medicine to treat various diseases …

Supramolecular Assembly in Live Cells Mapped by Real-Time Phasor-Fluorescence Lifetime Imaging

Y Ren, Z Zhou, K Maxeiner, A Kaltbeitzel… - Journal of the …, 2024 - ACS Publications
The complex dynamics and transience of assembly pathways in living systems complicate
the understanding of these molecular to nanoscale processes. Current technologies are …

Glucose transporter 3 (GLUT3) promotes lactylation modifications by regulating lactate dehydrogenase A (LDHA) in gastric cancer

H Yang, S Yang, J He, W Li, A Zhang, N Li… - Cancer Cell …, 2023 - Springer
Abstract Objectives Glucose transporter 3 (GLUT3) plays a major role in glycolysis and
glucose metabolism in cancer cells. We aimed to investigate the correlation between GLUT3 …

[HTML][HTML] Berberine modulates cardiovascular diseases as a multitarget-mediated alkaloid with insights into its downstream signals using in silico prospective …

S Almowallad, R Al-Massabi - Saudi Journal of Biological Sciences, 2024 - Elsevier
Atherosclerosis is potentially correlated with several cardiac disorders that are greatly
associated with cellular oxidative stress generation, inflammation, endothelial cells …