Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos

I Maji, S Mahajan, A Sriram, P Medtiya… - Journal of Controlled …, 2021 - Elsevier
A significant proportion of recently approved drug molecules possess poor aqueous
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …

[HTML][HTML] Current status of supersaturable self-emulsifying drug delivery systems

H Park, ES Ha, MS Kim - Pharmaceutics, 2020 - mdpi.com
Self-emulsifying drug delivery systems (SEDDSs) are a vital strategy to enhance the
bioavailability (BA) of formulations of poorly water-soluble compounds. However, these …

[HTML][HTML] Liquid and solid self-emulsifying drug delivery systems (SEDDs) as carriers for the oral delivery of azithromycin: optimization, in vitro characterization and …

R Abou Assi, I M. Abdulbaqi, T Seok Ming, C Siok Yee… - Pharmaceutics, 2020 - mdpi.com
Azithromycin (AZM) is a macrolide antibiotic used for the treatment of various bacterial
infections. The drug is known to have low oral bioavailability (37%) which may be attributed …

Recent advances in oral nano-antibiotics for bacterial infection therapy

ZL Wu, J Zhao, R Xu - International Journal of Nanomedicine, 2020 - Taylor & Francis
Bacterial infections are the main infectious diseases and cause of death worldwide.
Antibiotics are used to treat various infections ranging from minor to life-threatening ones …

[HTML][HTML] Formulation development of solid self-nanoemulsifying drug delivery systems of quetiapine fumarate via hot-melt extrusion technology: optimization using …

P Uttreja, AAA Youssef, I Karnik, K Sanil, N Narala… - Pharmaceutics, 2024 - mdpi.com
Quetiapine fumarate (QTF) was approved for the treatment of schizophrenia and acute
manic episodes. QTF can also be used as an adjunctive treatment for major depressive …

[HTML][HTML] Quality by design-based development of solid self-emulsifying drug delivery system (SEDDS) as a potential carrier for oral delivery of lysozyme

M Šahinović, A Hassan, K Kristó, G Regdon Jr… - Pharmaceutics, 2023 - mdpi.com
For many years, researchers have been making efforts to find a manufacturing technique, as
well as a drug delivery system, that will allow for oral delivery of biopharmaceuticals to their …

Self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel and carvacrol synergizes the anticancer activity and enables safer toxicity profile: optimization, and …

MAM Ateeq, M Aalhate, S Mahajan, GS Kumar… - Drug Delivery and …, 2023 - Springer
Docetaxel (DTX) is a first-line chemotherapeutic molecule with a broad-spectrum anticancer
activity. On the other hand, carvacrol (CV) has anti-inflammatory, antioxidant, cytotoxic, and …

Insights into novel excipients of self-emulsifying drug delivery systems and their significance: an updated review

ER Rani, GV Radha - Critical Reviews™ in Therapeutic Drug …, 2021 - dl.begellhouse.com
Self-emulsifying drug delivery system (SEDDS), a category of lipid-based technology, has
gained interest in the recent years for enhancement of solubility and bioavailability of poorly …

[HTML][HTML] The Science of Selecting Excipients for Dermal Self-Emulsifying Drug Delivery Systems

D van Staden, RK Haynes, JM Viljoen - Pharmaceutics, 2023 - mdpi.com
Self-emulsification is considered a formulation technique that has proven capacity to
improve oral drug delivery of poorly soluble drugs by advancing both solubility and …

The preparation and relative bioavailability of an artemisin in self-emulsifying drug delivery system

S Gao, J Chen, W Peng, Y Yang, Y Yang, L Hua… - Drug Delivery, 2023 - Taylor & Francis
The aim of this study is to demonstrate a method for improving the solubility and relative
bioavailability of artemisinin using a self-emulsifying drug delivery system (SEDDS). The self …