Mitochondria accumulate copper in their matrix for the eventual maturation of the
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …

The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …

Mitochondrial ribosomes translate membrane integral core subunits of the oxidative
phosphorylation system encoded by mtDNA. These translation products associate with …

Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance
between ROS and antioxidants contributes substantially to the physiological welfare of the …

Introduction Alzheimer's disease is the most common dementia with clinical and
pathological heterogeneity. Cuproptosis is a recently reported form of cell death, which …

Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for
virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed …

The genetic code that specifies the identity of amino acids incorporated into proteins during
protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations …

All known eukaryotes require copper for their development and survival. The essentiality of
copper reflects its widespread use as a co-factor in conserved enzymes that catalyze …

As the interface between the gut microbiota and the mucosal immune system, there has
been great interest in the maintenance of colonic epithelial integrity through mitochondrial …

The ultrastructure of the cardiac myocyte is remarkable for the high density of mitochondria
tightly packed between sarcomeres. This structural organization is designed to provide …