[HTML][HTML] Getting out what you put in: Copper in mitochondria and its impacts on human disease
Mitochondria accumulate copper in their matrix for the eventual maturation of the
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis, import, and assembly pathways
JX Tang, K Thompson, RW Taylor… - International Journal of …, 2020 - mdpi.com
The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …
Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein
R Richter-Dennerlein, S Oeljeklaus, I Lorenzi… - Cell, 2016 - cell.com
Mitochondrial ribosomes translate membrane integral core subunits of the oxidative
phosphorylation system encoded by mtDNA. These translation products associate with …
phosphorylation system encoded by mtDNA. These translation products associate with …
MicroRNA and ROS crosstalk in cardiac and pulmonary diseases
Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance
between ROS and antioxidants contributes substantially to the physiological welfare of the …
between ROS and antioxidants contributes substantially to the physiological welfare of the …
Identification and immunological characterization of cuproptosis-related molecular clusters in Alzheimer's disease
Y Lai, C Lin, X Lin, L Wu, Y Zhao, F Lin - Frontiers in aging …, 2022 - frontiersin.org
Introduction Alzheimer's disease is the most common dementia with clinical and
pathological heterogeneity. Cuproptosis is a recently reported form of cell death, which …
pathological heterogeneity. Cuproptosis is a recently reported form of cell death, which …
From synthesis to utilization: The ins and outs of mitochondrial heme
Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for
virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed …
virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed …
Molecular basis of translation termination at noncanonical stop codons in human mitochondria
M Saurer, M Leibundgut, HP Nadimpalli, A Scaiola… - Science, 2023 - science.org
The genetic code that specifies the identity of amino acids incorporated into proteins during
protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations …
protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations …
The mitochondrion: a central architect of copper homeostasis
All known eukaryotes require copper for their development and survival. The essentiality of
copper reflects its widespread use as a co-factor in conserved enzymes that catalyze …
copper reflects its widespread use as a co-factor in conserved enzymes that catalyze …
Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines
SA Smith, SA Ogawa, L Chau… - The Journal of …, 2021 - Am Soc Clin Investig
As the interface between the gut microbiota and the mucosal immune system, there has
been great interest in the maintenance of colonic epithelial integrity through mitochondrial …
been great interest in the maintenance of colonic epithelial integrity through mitochondrial …
Maintaining ancient organelles: mitochondrial biogenesis and maturation
RB Vega, JL Horton, DP Kelly - Circulation research, 2015 - Am Heart Assoc
The ultrastructure of the cardiac myocyte is remarkable for the high density of mitochondria
tightly packed between sarcomeres. This structural organization is designed to provide …
tightly packed between sarcomeres. This structural organization is designed to provide …