Developing novel therapeutics often follows three steps: target identification, design of
strategies to suppress target activity and drug development to implement the strategies. In …

Simple Summary Activating transcription factor 4 (ATF4) is a transcription factor known to
regulate genes associated with the sensing of cellular stress such as amino acid deprival …

According to previous research, turmeric seeds exhibit anti-inflammatory, anti-malignancy,
and anti-aging properties due to an abundance of terpinen-4-ol (T4O). Although it is still …

MYCN-amplified neuroblastoma often presents as a highly aggressive metastatic disease
with a poor prognosis. Activating transcription factor 5 (ATF5) is implicated in neural cell …

As in the case of cancer, the risk of infection increases when the host's immune system is not
working properly. It has been shown that toxins produced by the bacteria responsible for …

We have designed cell-penetrating peptides that target the leucine zipper transcription
factors ATF5, CEBPB and CEBPD and that promote apoptotic death of a wide range of …

Mitochondrial dysfunction underlines neurodegenerative diseases which are mostly
characterized by progressive degeneration of neurons. We previously reported that Cellular …

目的研究激活转录因子5 (ATF5) 在子宫内膜癌组织中的表达情况, 并探讨其临床意义.
方法利用生物信息学分析ATF5 在子宫内膜癌组织中的表达及与预后的关系 …

Cellular integrated stress response (ISR), the mitochondrial unfolded protein response
(UPRmt), and IFN signaling are associated with viral infections. Activating transcription factor …

Background Radiotherapy currently has become one of the major therapeutic approaches in
the treatments for cancers. However, hypoxia presents a significant challenge to the …