Introduction: P-glycoprotein (P-gp) is a multi-specific efflux transporter belonging to ATP-
binding cassette (ABC) transporter family, encoded by the ABCB1 gene, which significantly …

Highlights•Few new active drugs are proposed to treat acute myeloid leukemias.•New
formulations can change the efficiency of old drugs.•Nanomedicine can help to target the …

The hydrophobic character of most drug molecules and their potential for degradation under
the hostile environment of the gastrointestinal tract (GIT) constitutes the main obstacle in the …

Extensive attention has been focused on herbal medicine for the treatment of different
endocrine disorders. In fact, compelling scientific evidence indicates that natural compounds …

Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid‐
induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the …

Curcumin, a potent antioxidant polyphenol with neuroprotective and antiamyloid activities,
has significant potential in the treatment of neurodegenerative disorders such as Alzheimer's …

Triptolide (TP) often causes adverse reactions in the gastrointestinal tract when it is
administered orally. This study aimed to prepare and optimize triptolide-loaded solid lipid …

Drug loading capacity is an important property for an ideal drug delivery system. However,
the drug loading capacity of prepared pH-sensitive polymeric nanoparticles is usually low …

Nanotechnology has gained increased attention for delivering therapeutic agents effectively
to the cardiovascular system. Heart targeted nanocarrier based drug delivery is a new …

Abstract Human Immunodeficiency Virus (HIV) is a global health concern to which
nanomedicine approaches provide opportunities to improve the bioavailability of existing …