Early detection and diagnosis of many cancers is very challenging. Late stage detection of a
cancer always leads to high mortality rates. It is imperative to develop novel and more …

The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Designing nanozymes that match natural enzymes have always been an attractive and
challenging goal. In general, researchers mainly focus on the construction of metal centers …

Metal-organic frameworks (MOFs) with periodically arranged porphyrinic linkers avoiding
the self-quenching issue of porphyrins in photodynamic therapy (PDT) have been widely …

Immunotherapy has been considered as a potent antitumor modality while its efficacy is
frequently hampered by the insufficient immunogenicity and immunosuppressive tumor …

Metabolic heterogeneity and the tumor immunosuppressive microenvironment (TIME) of
triple-negative breast cancer (TNBC) hinder therapeutic effectiveness. Although emerging …

In this study, a bacterium-based lactate bioconsumer (designated Bac@ RFH) was
elaborately engineered for persistent lactate consumption to potentiate antitumor …

Cancer immunotherapy has become an established therapeutic paradigm in oncologic
therapy, but its therapeutic efficacy remains unsatisfactory in the majority of cancer patients …

Tumor suppressor p53 can transcriptionally activate downstream genes in response to
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …

Traditionally referred to as “metabolic junk”, lactate has now been recognized as essential
“energy currency” and crucial “messenger” that contributes to tumor evolution …