Adaptation of the brain to the presence of a drug predicts withdrawal on cessation. The
outcome of adaptation is often referred to as 'physical dependence'in pharmacology, as …

This article is a clinical guide which discusses the “state-of-the-art” usage of the classic
monoamine oxidase inhibitor (MAOI) antidepressants (phenelzine, tranylcypromine, and …

Background There is mounting interest in the potential efficacy of low carbohydrate and very
low carbohydrate ketogenic diets in various neurological and psychiatric disorders. Aims To …

We now recognise that withdrawal symptoms from antidepressants are common, and can be
severe and long-lasting in some people. Many withdrawal symptoms overlap with symptoms …

Variants in KCNT1, encoding a sodium-gated potassium channel (subfamily T member 1),
have been associated with a spectrum of epilepsies and neurodevelopmental disorders …

Although psychiatric drug withdrawal syndromes have been recognized since the 1950s–
recent studies confirm antidepressant withdrawal syndrome incidence upwards of 40 …

The dominant view within mental health services and research suggests that feeling
depressed is a kind of medical illness, partially caused by various biological deficits which …

Background Many people experience withdrawal symptoms when they attempt to stop
antidepressants. Withdrawal symptoms are readily misconstrued for relapse or ongoing …

Background: Tapering strips facilitate antidepressant discontinuation, allowing for
personalised titration of discontinuation to the intensity of withdrawal. A tapering strip …

Antidepressant drugs are prescribed to patients with depressive, anxiety disorders, and
other conditions. Evidence about antidepressant discontinuation syndrome (ADS) and …