Glycosyltransferase-catalyzed synthesis of bioactive oligosaccharides

CAGM Weijers, MCR Franssen, GM Visser - Biotechnology advances, 2008 - Elsevier
Mammalian cell surfaces are all covered with bioactive oligosaccharides which play an
important role in molecular recognition events such as immune recognition, cell–cell …

Glycosyltransferases as biocatalysts

MM Palcic - Current opinion in chemical biology, 2011 - Elsevier
Glycosyltransferases are useful synthetic tools for the preparation of natural
oligosaccharides, glycoconjugates and their analogues. High expression levels of …

Enzymatic and chemoenzymatic synthesis of human milk oligosaccharides and derivatives

J Zheng, H Xu, J Fang, X Zhang - Carbohydrate Polymers, 2022 - Elsevier
Human milk oligosaccharides (HMOs) are complex glycans that are the third largest solid
component in human milk. It has attracted great interest in recent years due to their critical …

A Redox‐Controlled Substrate Engineering Strategy for Site‐Specific Enzymatic Fucosylation

N Lu, Y Li, H Xia, K Zhong, C Jia, J Ye, X Liu… - Angewandte …, 2022 - Wiley Online Library
Fucosylation is one of the most common modifications of oligo‐N‐acetyllactosamine (oligo‐
LacNAc) glycans. However, none of known fucosyltransferases (FucTs) could install the α1 …

An overview on biological production of functional lactose derivatives

Y Xiao, Q Chen, C Guang, W Zhang, W Mu - Applied microbiology and …, 2019 - Springer
Lactose is a natural disaccharide obtained from the milk of most mammals and a waste
product of cheese and casein manufacturing. Over the past decades, lactose in whey has …

Recent development of analytical methods for disease-specific protein O-GlcNAcylation

W Hu, G Zhang, Y Zhou, J Xia, P Zhang, W Xiao… - RSC …, 2023 - pubs.rsc.org
The enzymatic modification of protein serine or threonine residues by N-acetylglucosamine,
namely O-GlcNAcylation, is a ubiquitous post-translational modification that frequently …

Recent developments in enzymatic synthesis of modified sialic acid derivatives

CC Yu, SG Withers - Advanced Synthesis & Catalysis, 2015 - Wiley Online Library
Sialic acid‐containing glycans play important roles in biology, but their synthesis by
standard chemical approaches is challenging. Enzymatic assembly is generally a better …

Glycosyltransferase‐catalyzed synthesis of thiooligosaccharides

JR Rich, A Szpacenko, MM Palcic… - Angewandte Chemie …, 2004 - Wiley Online Library
S-Linked oligomers are metabolically stable mimics of their naturally occurring counterparts,
since the rate of hydrolysis of the thioglycosidic bond by glycosylhydrolases is several …

Synthesis and modifications of carbohydrates, using biotransformations

AM Daines, BA Maltman, SL Flitsch - Current Opinion in Chemical Biology, 2004 - Elsevier
Enzymes continue to be used as important catalysts, for the generation of rare and
'unnatural'monosaccharides and for the selective formation of glycosidic linkages. Multi …

Ionic-liquid-based catch and release mass spectroscopy tags for enzyme monitoring

MC Galan, AT Tran, C Bernard - Chemical communications, 2010 - pubs.rsc.org
A novel, inexpensive and versatile ionic-liquid-based catch and release mass spectrometry
tag (I-Tag) that facilitates substrate purification, fast, robust and sensitive enzymatic reaction …