Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …

Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …

Few studies have explored the impact of rare variants (minor allele frequency< 1%) on
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …

Abstract Type 2 diabetes (T2D) associated health disparities among different ethnicities
have long been known. Ethnic variations also exist in T2D related comorbidities including …

The kidneys operate at the interface of plasma and urine by clearing molecular waste
products while retaining valuable solutes. Genetic studies of paired plasma and urine …

Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …

Transcriptomics data have been integrated with genome-wide association studies (GWASs)
to help understand disease/trait molecular mechanisms. The utility of metabolomics …

Cow's milk is frequently included in the human diet, but the relationship between milk intake
and type 2 diabetes (T2D) remains controversial. Here, using data from the Hispanic …

Circulating metabolite levels may reflect the state of the human organism in health and
disease, however, the genetic architecture of metabolites is not fully understood. We have …

Age-related macular degeneration (AMD) is a leading cause of blindness in older adults.
Investigating shared genetic components between metabolites and AMD can enhance our …