Melatonin is a neurohormone involved in the regulation of both acute and chronic pain
whose mechanism is still not completely understood. We have recently demonstrated that …

The search for melatonin receptor agonists formed the main part of melatonin medicinal
chemistry programs for the last three decades. In this short review, we summarize the two …

Melatonin, a neurohormone that binds to two G protein‐coupled receptors MT1 and MT2, is
involved in pain regulation, but the distinct role of each receptor has yet to be defined. We …

Procedures carried out with a needle are the most important sources of pain for children.
Pain causes children to be frightened of needles and this leads children to unwillingness to …

Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …

The melatonin system and circadian disruption have well‐established links with aggressive
behaviors; however, the biological underpinnings have not been thoroughly investigated …

Melatonin, an indoleamine hormone secreted into circulation at night primarily by the brain's
pineal gland, has been shown to have a wide variety of actions on the development and …

The pineal gland (Glandula Pinealis) was first described by the Greek medical physician,
surgeon and philosopher Galen (131 CE-201 CE). He named the gland from the …

Melatonin (MLT) is a neurohormone implicated in several physiological processes such as
sleep. Contrasting results have been produced on whether or not it may act as a hypnotic …

Background Global cerebral ischemia (GCI) elicits damages to cerebral structures, learning
dysfunction, memory impairments, hyperactivity, and anxiety. Circulating levels of galectin-3 …