Lactate dehydrogenase kinetics predict chemotherapy response in recurrent metastatic nasopharyngeal carcinoma

L Huang, AYL Sim, Y Wu, Z Liang, K Li… - Therapeutic …, 2020 - journals.sagepub.com
Background: Lactate dehydrogenase (LDH) is a known prognostic biomarker for the
endemic variant of nasopharyngeal carcinoma (NPC). Here, we investigate whether serial …

Radiation therapy reduced blood levels of LDH, HIF-1α, and miR-210 in OSCC

MG de Souza, SF de Jesus, EM Santos… - Pathology & Oncology …, 2020 - Springer
Radiation Therapy (RT) is a treatment option for a large number of neoplasias. However, the
effect of RT on the level of hypoxia markers is poorly understood. The present study aimed to …

[HTML][HTML] Pien Tze Huang regulates phosphorylation of metabolic enzymes in mice of hepatocellular carcinoma

J Lin, S Wang, W Lan, M Ji, M Li - Scientific Reports, 2023 - nature.com
Abstract The Chinese medicine formula Pien Tze Huang (PZH) has been applied to the
treatment of various diseases, the reported anti-tumor mechanisms included regulation of …

[HTML][HTML] Tumor microenvironment and immune response in lip cancer

AG Gkegka, MI Koukourakis, M Lambropoulou… - Cancers, 2023 - mdpi.com
Simple Summary The presence of tumor-infiltrating lymphocytes (TILs) in the tumor milieu
has been linked to better patient prognosis and response to chemo-radiotherapy in head …

[HTML][HTML] Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling

R Jiang, S Luo, M Zhang, W Wang, S Zhuo… - Molecular Genetics and …, 2023 - Springer
This study aimed to investigate the effects of Ginsenoside Rh4 (Rh4) on inflammation-
related hepatocellular carcinoma (HCC) progression and the underlying mechanism. HCC …

[HTML][HTML] NORAD modulates miR-30c-5p-LDHA to protect lung endothelial cells damage

Y Zhou, C Chen, Q Li, H Sheng, X Guo, E Mao - Open Medicine, 2022 - degruyter.com
Acute lung injury (ALI) is a devastating human malignancy characterized by excessively
uncontrolled inflammation and lung endothelial dysfunction. Non-coding RNAs play …

Polymorphisms in glycolysis-related genes are associated with clinical outcomes of paclitaxel-cisplatin chemotherapy in non-small cell lung cancer

SH Choi, CC Jin, SK Do, SY Lee, JE Choi, HG Kang… - Oncology, 2020 - karger.com
Objective: This study was conducted to investigate whether polymorphisms in glycolysis-
related genes are associated with clinical outcomes of patients with advanced-stage non …

Targeted inhibition of HK-II reversed the Warburg effect to improve the radiosensitivity of laryngeal carcinoma

XH Chen, DL Yu, JT Zhong, SH Zhou… - Cancer Management …, 2021 - Taylor & Francis
Purpose Hexokinase-II (HK-II) is the key enzyme in the first rate-limiting step of glycolysis
that catalyzes the conversion of glucose to glucose-6-phosphate. Here, we examined the …

Hypoxia and acidity regulate immune checkpoint molecule and IFN-β expression in non-small cell lung cancer cell lines

AG Mitrakas, A Giatromanolaki… - Journal of Receptors …, 2023 - Taylor & Francis
Purpose Non-small cell lung cancer (NSCLC) is one of the most lethal tumors in humans.
Immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the treatment of …

[HTML][HTML] Metabolic Tolerance to Atmospheric Pressure of Two Freshwater Endemic Amphipods Mostly Inhabiting the Deep-Water Zone of the Ancient Lake Baikal

E Madyarova, Y Shirokova, A Gurkov, P Drozdova… - Insects, 2022 - mdpi.com
Simple Summary Deep-water habitats are the largest ecosystem on the planet: over half of
the Earth's surface is covered with a water layer deeper than 200 m and remains poorly …