Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder
The serotonin deficit hypothesis explanation for major depressive disorder (MDD) has
persisted among clinicians and the general public alike despite insufficient supporting …
persisted among clinicians and the general public alike despite insufficient supporting …
Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression
RH Asch, CG Abdallah, RE Carson… - …, 2024 - nature.com
The development of novel radiotracers for Positron Emission Tomography (PET) imaging
agents targeting the synaptic vesicle glycoprotein 2 A (SV2A), an integral glycoprotein …
agents targeting the synaptic vesicle glycoprotein 2 A (SV2A), an integral glycoprotein …
An in vivo high-resolution human brain atlas of synaptic density
A Johansen, V Beliveau, E Colliander… - Journal of …, 2024 - jneurosci.org
Synapses are fundamental to the function of the central nervous system and are implicated
in a number of brain disorders. Despite their pivotal role, a comprehensive imaging resource …
in a number of brain disorders. Despite their pivotal role, a comprehensive imaging resource …
The effect of antidepressant treatment on blood BDNF levels in depressed patients: A review and methodological recommendations for assessment of BDNF in blood
CA Madsen, ML Navarro, B Elfving, LV Kessing… - European …, 2024 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a leading
cause of disability worldwide. Brain-derived neurotrophic factor (BDNF), a signaling protein …
cause of disability worldwide. Brain-derived neurotrophic factor (BDNF), a signaling protein …
A link between ghrelin and major depressive disorder: a mini review
M Lis, T Miłuch, M Majdowski, T Zawodny - Frontiers in psychiatry, 2024 - frontiersin.org
Ghrelin is primarily responsible for regulating energy balance, as it increases appetite.
However, in recent years, its new physiological functions have been discovered—it …
However, in recent years, its new physiological functions have been discovered—it …
Effect of antidepressant treatment on 5-HT4 receptor binding and associations with clinical outcomes and verbal memory in major depressive disorder
ABSTRACT Background Brain serotonin 4 receptor (5-HT 4 R) levels are lower in untreated
patients with Major Depressive Disorder (MDD) and are linked to verbal memory. We here …
patients with Major Depressive Disorder (MDD) and are linked to verbal memory. We here …
[HTML][HTML] A single subanaesthetic dose of the rapid-acting antidepressant S-ketamine raises presynaptic SV2A density in limbic regions of the Wistar Kyoto rat model of …
SL Bærentzen, AL Waszkiewicz, M Thomsen… - Neuroscience …, 2024 - Elsevier
The N-methyl-D-aspartate receptor (NMDA-R) antagonist S-ketamine has been approved as
a rapid-acting antidepressant for treatment-resistant depression (TRD). The antidepressant …
a rapid-acting antidepressant for treatment-resistant depression (TRD). The antidepressant …
A melancholy machine: simulated synapse loss induces depression-like behaviors in deep reinforcement learning
E Chalmers, S Duarte, X Al-Hejji, D Devoe, A Gruber… - bioRxiv, 2024 - biorxiv.org
Deep Reinforcement Learning is a branch of artificial intelligence that uses artificial neural
networks to model reward-based learning as it occurs in biological agents. Here we modify a …
networks to model reward-based learning as it occurs in biological agents. Here we modify a …
Ligands of the trace amine-associated receptors (TAARs): A new class of anxiolytics.
Y Alnefeesi, I Sukhanov… - Pharmacology …, 2024 - europepmc.org
Most cases of anxiety are currently treated with either benzodiazepines or serotonin
reuptake inhibitors. These drugs carry with them risks for a multitude of side effects, and …
reuptake inhibitors. These drugs carry with them risks for a multitude of side effects, and …
[PDF][PDF] Neural correlates of the big five personality traits: Understanding the brain basis of openness, conscientiousness, extroversion, agreeableness, and neuroticism
KH Chia, DMK Tan - The Asian Educational Therapist, 2024 - paediatrictx.com
This paper explores the neural underpinnings of the Big Five Personality Traits (BFPTs)-
Openness to Experience [O], Conscientiousness [C], Extroversion 3 [E], Agreeableness [A] …
Openness to Experience [O], Conscientiousness [C], Extroversion 3 [E], Agreeableness [A] …