Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Abstract Non-benzodiazepine hypnotics (“Z-drugs”) are prescribed for insomnia, but might
increase risk of motor vehicle crash (MVC) among older adults through prolonged …

Background Many medications impair driving skills yet their influence on collision risk
remains uncertain. We aimed to systematically investigate the risk of collision responsibility …

Aim To investigate the impact of antidepressants on the risk of road traffic crash in the
elderly. Methods Reports from the U niversal Q uebec A utomobile I nsurance A gency …

Aims Non-steroidal anti-inflammatory drugs (NSAIDs), particularly selective COX-2
inhibitors, are associated with an increased risk of cardiovascular adverse events. However …

The European DRUID (Drive Under the Influence of drugs, alcohol, and medicines) program
classifies medications into three categories according to their effect on one's fitness to drive …

Background: Benzodiazepines, Z-drugs, pregabalin, and melatonin (BZPMs) have been
associated with a higher risk of traffic accidents, but the evidence is inconsistent, and lacking …

Background First‐generation antihistamines are considered driving‐impairing medicines
(DIM), while second‐and third‐generation antihistamines are relatively safe for driving …

Purpose In exploratory analyses of pharmacoepidemiological data from large populations
with large number of exposures, both a conceptual and computational problem is how to …

Background The case‐crossover (CXO) and self‐controlled case series (SCCS) designs are
increasingly used in pharmacoepidemiology. In both, relative risk estimates are obtained …