Lysosomes: signaling hubs for metabolic sensing and longevity
Lysosomes are sites of active metabolism in a cell. They contain various hydrolases that
degrade extracellular and intracellular materials during endocytosis and autophagy …
degrade extracellular and intracellular materials during endocytosis and autophagy …
The rate of telomere loss is related to maximum lifespan in birds
GM Tricola, MJP Simons, E Atema… - … of the Royal …, 2018 - royalsocietypublishing.org
Telomeres are highly conserved regions of DNA that protect the ends of linear
chromosomes. The loss of telomeres can signal an irreversible change to a cell's state …
chromosomes. The loss of telomeres can signal an irreversible change to a cell's state …
Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?
JM Van Raamsdonk, S Hekimi - Antioxidants & redox signaling, 2010 - liebertpub.com
The free radical theory of aging proposes a causal relationship between reactive oxygen
species (ROS) and aging. While it is clear that oxidative damage increases with age, its role …
species (ROS) and aging. While it is clear that oxidative damage increases with age, its role …
[图书][B] Advanced thermodynamics engineering
K Annamalai, IK Puri, MA Jog - 2011 - taylorfrancis.com
Advanced Thermodynamics Engineering, Second Edition is designed for readers who need
to understand and apply the engineering physics of thermodynamic concepts. It employs a …
to understand and apply the engineering physics of thermodynamic concepts. It employs a …
Quantitative analysis of compensatory and catch‐up growth in diverse taxa
KL Hector, S Nakagawa - Journal of Animal Ecology, 2012 - Wiley Online Library
'Compensatory growth'and 'catch‐up growth'are often used interchangeably to describe the
faster than optimal growth that occurs following a period of dietary restriction in the …
faster than optimal growth that occurs following a period of dietary restriction in the …
[HTML][HTML] Early mitochondrial dysfunction in long-lived Mclk1+/-mice
J Lapointe, S Hekimi - Journal of Biological Chemistry, 2008 - ASBMB
Reduced activity of CLK-1/MCLK1 (also known as COQ7), a mitochondrial enzyme that is
necessary for ubiquinone biosynthesis, prolongs the lifespan of nematodes and mice by a …
necessary for ubiquinone biosynthesis, prolongs the lifespan of nematodes and mice by a …
[HTML][HTML] Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease
The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome,
comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation …
comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation …
Energy expenditure and activity among Hadza hunter‐gatherers
Objectives Studies of total energy expenditure,(TEE; kcal/day) among traditional populations
have challenged current models relating habitual physical activity to daily energy …
have challenged current models relating habitual physical activity to daily energy …
ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide.
As a result, novel therapies are still needed to protect the heart from the detrimental effects of …
As a result, novel therapies are still needed to protect the heart from the detrimental effects of …
Pollinator size and its consequences: Robust estimates of body size in pollinating insects
Body size is an integral functional trait that underlies pollination‐related ecological
processes, yet it is often impractical to measure directly. Allometric scaling laws have been …
processes, yet it is often impractical to measure directly. Allometric scaling laws have been …