Lysosomes: signaling hubs for metabolic sensing and longevity

M Savini, Q Zhao, MC Wang - Trends in cell biology, 2019 - cell.com
Lysosomes are sites of active metabolism in a cell. They contain various hydrolases that
degrade extracellular and intracellular materials during endocytosis and autophagy …

The rate of telomere loss is related to maximum lifespan in birds

GM Tricola, MJP Simons, E Atema… - … of the Royal …, 2018 - royalsocietypublishing.org
Telomeres are highly conserved regions of DNA that protect the ends of linear
chromosomes. The loss of telomeres can signal an irreversible change to a cell's state …

Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?

JM Van Raamsdonk, S Hekimi - Antioxidants & redox signaling, 2010 - liebertpub.com
The free radical theory of aging proposes a causal relationship between reactive oxygen
species (ROS) and aging. While it is clear that oxidative damage increases with age, its role …

[图书][B] Advanced thermodynamics engineering

K Annamalai, IK Puri, MA Jog - 2011 - taylorfrancis.com
Advanced Thermodynamics Engineering, Second Edition is designed for readers who need
to understand and apply the engineering physics of thermodynamic concepts. It employs a …

Quantitative analysis of compensatory and catch‐up growth in diverse taxa

KL Hector, S Nakagawa - Journal of Animal Ecology, 2012 - Wiley Online Library
'Compensatory growth'and 'catch‐up growth'are often used interchangeably to describe the
faster than optimal growth that occurs following a period of dietary restriction in the …

[HTML][HTML] Early mitochondrial dysfunction in long-lived Mclk1+/-mice

J Lapointe, S Hekimi - Journal of Biological Chemistry, 2008 - ASBMB
Reduced activity of CLK-1/MCLK1 (also known as COQ7), a mitochondrial enzyme that is
necessary for ubiquinone biosynthesis, prolongs the lifespan of nematodes and mice by a …

[HTML][HTML] Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease

ES Chocron, E Munkácsy, AM Pickering - Biochimica et Biophysica Acta …, 2019 - Elsevier
The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome,
comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation …

Energy expenditure and activity among Hadza hunter‐gatherers

H Pontzer, DA Raichlen, BM Wood… - American Journal of …, 2015 - Wiley Online Library
Objectives Studies of total energy expenditure,(TEE; kcal/day) among traditional populations
have challenged current models relating habitual physical activity to daily energy …

ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies

S Lecour, HE Bøtker, G Condorelli… - Cardiovascular …, 2014 - academic.oup.com
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide.
As a result, novel therapies are still needed to protect the heart from the detrimental effects of …

Pollinator size and its consequences: Robust estimates of body size in pollinating insects

LK Kendall, R Rader, V Gagic… - Ecology and …, 2019 - Wiley Online Library
Body size is an integral functional trait that underlies pollination‐related ecological
processes, yet it is often impractical to measure directly. Allometric scaling laws have been …