Therapeutic resistance and metastatic progression are responsible for the majority of cancer
mortalities. In particular, the development of resistance is a significant barrier to the efficacy …

Phenotypic and functional heterogeneity arise among cancer cells within the same tumour
as a consequence of genetic change, environmental differences and reversible changes in …

Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal
properties and the capacity to seed tumours. CSCs are typically refractory to conventional …

Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive
study. Their properties and mechanisms of formation have become a major focus of current …

Glioblastoma multiforme is the most common primary malignant brain tumour, with a median
survival of about one year. This poor prognosis is due to therapeutic resistance and tumour …

Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived
from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of …

Xenograft cell transplantation into immunodeficient mice has become the gold standard for
assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single-cell …

Cancer stem cells (CSCs) have been proposed as the driving force of tumorigenesis and the
seeds of metastases. However, their existence and role remain a topic of intense debate …

Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities
of self-renewal, differentiation, and tumorigenicity when transplanted into an animal host. A …

Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …