Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …

Advances over the past few years have begun to enable prediction and design of
macromolecular structures at near-atomic accuracy. Progress has stemmed from the …

The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …

The COVID-19 pandemic continues to be a public health threat with emerging variants of
SARS-CoV-2. Nirmatrelvir (PF-07321332) is a reversible, covalent inhibitor targeting the …

Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …

Three-dimensional (3D) structure determination by single-particle analysis of cryo-electron
microscopy (cryo-EM) images requires many parameters to be determined from extremely …

CrystFEL is a suite of programs for processing data fromserial crystallography'experiments,
which are usually performed using X-ray free-electron lasers (FELs) but also increasingly …

Potassium channels selectively conduct K+ ions across cellular membranes with
extraordinary efficiency. Their selectivity filter exhibits four binding sites with approximately …

Current methods for determining ambient redox potential in cells are labor-intensive and
generally require destruction of tissue. This precludes single cell or real time studies of …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …